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https://repositorio.ufba.br/handle/ri/16603
metadata.dc.type: | Artigo de Periódico |
Título : | Clinical manifestations in individuals with recent diagnosis of HTLV type I infection |
Otros títulos : | Journal of Clinical Virology |
Autor : | Poetker, Shelene K. W. Porto, Maria Aurélia da Fonseca Giozza, Silvana P. Muniz, André Luís Nunes Caskey, Marina F. Carvalho Filho, Edgar Marcelino de Glesby, Marshall J. |
metadata.dc.creator: | Poetker, Shelene K. W. Porto, Maria Aurélia da Fonseca Giozza, Silvana P. Muniz, André Luís Nunes Caskey, Marina F. Carvalho Filho, Edgar Marcelino de Glesby, Marshall J. |
Resumen : | Background: Human T-lymphotropic virus type 1 (HTLV-1) is known to cause HTLV-associated myelopathy (HAM)/tropical spastic paraparesis and adult T cell leukemia. A growing body of evidence links HTLV-1 infection with an increasing spectrum of disease, including uveitis, periodontal disease, arthropathy, sicca syndrome, and neurologic deficits. Objectives: Despite recent findings, the natural history of HTLV-1 infection remains poorly defined. This study was designed to better characterize initial clinical and neurological findings in individuals diagnosed with HTLV-1 infection. Study design: We conducted a cross-sectional study of 71 individuals recently diagnosed with HTLV-1 and 71 uninfected age- and sex-matched blood donors in Salvador, Brazil. Subjects were administered a standardized questionnaire and underwent physical exam. Results: HTLV-1 infected subjects were significantly more likely than controls to report complaints of hand and foot numbness (OR = 5.3; 95% CI: 1.8–15.3; p = 0.002 and OR = 4.0; 95% CI: 1.3–12; p = 0.013 respectively), difficulty running (OR = 4.0; 95% CI: 1.1–14.2; p = 0.032), nocturia (OR = 5.0; 95% CI: 1.1–22.8; p = 0.038), arthralgia (OR = 3.3; 95% CI: 1.4–7.7; p = 0.006), and photophobia (OR = 3.3; 95% CI: 1.4–7.7; p = 0.006). Conclusions: Neurologic, ocular and rheumatologic complaints may be the first manifestations of HTLV-1 infection. Therefore, all patients presenting with initial diagnosis should be rigorously screened for these symptoms. |
Palabras clave : | HTLV-1 Neurologic manifestations Clinical manifestations Neuropathy Natural history |
metadata.dc.rights: | Acesso Aberto |
URI : | http://repositorio.ufba.br/ri/handle/ri/16603 |
Fecha de publicación : | 2011 |
Aparece en las colecciones: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Aurelia F. Portoa.pdf | 146,13 kB | Adobe PDF | Visualizar/Abrir |
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