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https://repositorio.ufba.br/handle/ri/16386
metadata.dc.type: | Artigo de Periódico |
Título : | CD1a-positive Langerhans cells and their relationship with E-cadherin in ameloblastomas and keratocystic odontogenic tumors |
Otros títulos : | Journal of Oral Pathology and Medicine |
Autor : | Mello, Leonardo Araújo Figueiredo, Andréia Leal Ramos, Eduardo Antônio Gonçalves Gurgel, Clarissa Araujo Silva Martins, Manoela Domingues Figueiredo, Claúdia Roberta Leite Vieira de Cury, Patricia Ramos Albuquerque Júnior, Ricardo Luiz Cavalcanti de Ramalho, Luciana Maria Pedreira Santos, Jean Nunes dos |
metadata.dc.creator: | Mello, Leonardo Araújo Figueiredo, Andréia Leal Ramos, Eduardo Antônio Gonçalves Gurgel, Clarissa Araujo Silva Martins, Manoela Domingues Figueiredo, Claúdia Roberta Leite Vieira de Cury, Patricia Ramos Albuquerque Júnior, Ricardo Luiz Cavalcanti de Ramalho, Luciana Maria Pedreira Santos, Jean Nunes dos |
Resumen : | Background: Ameloblastomas and keratocystic odontogenic tumors (KOTs) are lesions that are characterized by locally invasive growth and cause extensive bone destruction. In addition, it is known that E-cadherin influences the adhesion of Langerhans cells (LCs) to keratinocytes. Objective and Methods: The aim of this study was to investigate, using immunohistochemistry, the distribution of CD1a-positive cells in ameloblastomas and KOTs and their relationship with E-cadherin, in comparison to calcifying cystic odontogenic tumor (CCOT). Results: The CD1a-positive LCs were observed in 11 ameloblastomas and KOTs. All of the cases of CCOT showed CD1a-positive LCs and a significant difference was found when this tumor was compared with ameloblastomas (P < 0.05, Mann–Whitney test). A statistically significant difference was also noted when comparing CD1a-positive LCs between CCOTs and KOTs (P < 0.05, Mann–Whitney test). Lower expression of E-cadherin in ameloblastomas (AMs) in relation to KOTs and CCOTs (P < 0.05, Fisher test) was observed. There was no correlation between E-cadherin and CD1a-positive LCs between all odontogenic tumors that were studied (P > 0.05, Spearman test). Conclusion: A quantitative difference of CD1a-positive cells between AMs and KOTs in comparison to CCOTs was observed. This permits to speculate that a depletion of CD1a-positive LCs might influence the local invasiveness of ameloblastomas and KOTs. Furthermore, it is suggested that E-cadherin mediates cell adhesion in these tumors. |
Palabras clave : | Dendritic cell E-cadherin Langerhans cell Odontogenic tumors |
metadata.dc.rights: | Acesso Aberto |
URI : | http://repositorio.ufba.br/ri/handle/ri/16386 |
Fecha de publicación : | 2013 |
Aparece en las colecciones: | Artigo Publicado em Periódico (Faculdade de Odontologia) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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10.1111-jop.12033.pdf | 515,52 kB | Adobe PDF | Visualizar/Abrir |
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