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metadata.dc.type: | Artigo de Periódico |
Title: | Obtaining concomitant control of allergic rhinitis and asthma with a nasally inhaled corticosteroid |
Other Titles: | Allergy |
Authors: | Camargos, Paulo Augusto Moreira Ibiapina, C. Lasmar, L. Cruz Filho, Álvaro Augusto Souza da |
metadata.dc.creator: | Camargos, Paulo Augusto Moreira Ibiapina, C. Lasmar, L. Cruz Filho, Álvaro Augusto Souza da |
Abstract: | Allergic rhinitis (AR) and asthma coexist frequently and a dual treatment is recommended by prescribing topical nasal plus oral inhaled corticosteroids. The purpose of this study was to assess the efficacy of a nasally inhaled corticosteroid aiming at concomitant control of AR and asthma. A controlled trial was conducted among 60 patients with AR and asthma, aged 6–18 years, who were randomized into two groups. During 8 weeks, the experimental group (30 patients) received exclusively fluticasone propionate hydrofluoroalkane (FP-HFA) inhaled through the nose (mouth closed) using a large volume spacer attached to a face mask. The comparison group (30 patients) received a nasal spray of isotonic saline plus oral inhalation of FP-HFA through a mouthpiece attached to the same spacer. Clinical scores for AR and asthma, nasal inspiratory peak flow (NIPF), and spirometry were assessed by blinded observers. There was a significant improvement in AR scores and NIPF in the experimental group (P ≤ 0.01) up to week 8, when a worsening was observed after the intervention was interrupted. Asthma symptoms score, forced expiratory volume (FEV)1, and FEF25−75% were not statistically different between groups at the baseline visit or along follow-up visits (P ≥ 0.20). Prebronchodilator FEV1 (% predicted value) improved by 10% in both groups, comparing values at inclusion with those obtained at the end of follow up. Our results suggest that nasally inhaled FP-HFA through a spacer may control AR and asthma in children and adolescents. This approach is likely to result in higher compliance, lower costs, and fewer side effects. |
Keywords: | Allergic rhinitis Asthma Inhaled corticosteroid |
metadata.dc.rights: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/15990 |
Issue Date: | 2007 |
Appears in Collections: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Files in This Item:
File | Description | Size | Format | |
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j.1398-9995.2007.01241.x.pdf | 510,24 kB | Adobe PDF | View/Open |
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