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https://repositorio.ufba.br/handle/ri/15911
metadata.dc.type: | Artigo de Periódico |
Title: | CD8+ T cells in situ in different clinical forms of human cutaneous leishmaniasis |
Other Titles: | Revista da Sociedade Brasileira de Medicina Tropical |
Authors: | Dantas, Marina Loyola Oliveira, Juliana Cabral de Carvalho, Lucas Pedreira de Passos, Sara Timóteo Queiroz, Adriano Machado, Paulo Roberto Lima Carvalho Filho, Edgar Marcelino de Arruda, Sérgio Marcos |
metadata.dc.creator: | Dantas, Marina Loyola Oliveira, Juliana Cabral de Carvalho, Lucas Pedreira de Passos, Sara Timóteo Queiroz, Adriano Machado, Paulo Roberto Lima Carvalho Filho, Edgar Marcelino de Arruda, Sérgio Marcos |
Abstract: | Introduction: Leishmania braziliensis infection induces a large spectrum of lesions that clinically manifest as nodules or papules that progress to ulcers. Although it is already known that T helper cells predominate in the lesions, cytotoxic T cells have also been reported to be present, and their role in leishmaniasis immunopathogenesis is not well known. This study investigated the amounts of CD8+ and granzyme B+ cells in different clinical forms of human cutaneous leishmaniasis (CL). Methods: Forty tissue fragments from early (E-CL) and late CL (L-CL) lesions and from disseminated leishmaniasis (DL) - papules and ulcers - were characterized. The inflamed area per fragment was calculated, and the CD8 and granzyme B expression levels in the infiltrates were quantified by counting positive cells in 15 fields. The localization of CD8 and granzyme B was graded subjectively. Results: Inflammation was higher in L-CL and DL ulcers. CD8 expression was increased in late ulcerated lesions compared to recent lesions. The increase in CD8+ cells also correlated with the duration of the lesion. Papules had a higher frequency of granzyme B+ cells than E-CL lesions, although the frequency was similar to those for late and DL ulcers. CD8+ cells were mostly found in the papillary dermis. Conclusions: CD8+ T and granzyme B+ cells are present in the inflammatory infiltrates of CL and DL and may participate in the immunopathogenesis of Leishmania infection. |
Keywords: | Leishmaniasis Cytotoxicity Inflammation Cutaneous CD8 Human |
metadata.dc.publisher.country: | Brasil |
metadata.dc.rights: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/15911 |
Issue Date: | 2013 |
Appears in Collections: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Files in This Item:
File | Description | Size | Format | |
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0037-8682-rsbmt-46-06-728.pdf | 2,42 MB | Adobe PDF | View/Open |
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