Please use this identifier to cite or link to this item: https://repositorio.ufba.br/handle/ri/15697
metadata.dc.type: Artigo de Periódico
Title: The effect of single and multiple infections on atopy and wheezing in children
Other Titles: Journal of Allergy and Clinical Immunology
Authors: Alcântara-Neves, Neuza Maria
Veiga, Rafael Valente
Dattoli, Vitor Camilo Cavalcante
Fiaccone, Rosimeire Leovigildo
Esquivel, Renata
Cruz Filho, Álvaro Augusto Souza da
Cooper, Philip John
Rodrigues, Laura Cunha
Barreto, Mauricio Lima
metadata.dc.creator: Alcântara-Neves, Neuza Maria
Veiga, Rafael Valente
Dattoli, Vitor Camilo Cavalcante
Fiaccone, Rosimeire Leovigildo
Esquivel, Renata
Cruz Filho, Álvaro Augusto Souza da
Cooper, Philip John
Rodrigues, Laura Cunha
Barreto, Mauricio Lima
Abstract: Background The current epidemic of asthma and atopy has been explained by alterations in immune responses related to reduction in childhood infections. However, the findings of epidemiologic studies investigating the association between infection with atopy and asthma have been inconsistent. Objective We sought to investigate the effect of single or multiple infections (pathogen burden) on atopy and wheeze in urban children from Latin America. Methods Specific IgE against aeroallergens (sIgE) and skin prick test (SPT) reactivity for the most common local allergens were measured in 1128 children aged 4 to 11 years. Data on wheezing and potential confounders were collected by questionnaire. Infections by 8 pathogens were assessed by using serology and stool examination. Associations of wheeze and atopic outcomes with single and multiple infections were analyzed by means of logistic regression. Results Negative results for Toxoplasma gondii were associated with a higher prevalence of sIgE (≥0.70 kU/L), whereas negative results for Ascaris lumbricoides, T gondii, herpes simplex virus, and EBV were associated with a higher prevalence of SPT reactivity. Children with 3 or fewer infection markers had a higher prevalence of sIgE and SPT reactivity compared with those with 4 or more infection markers. However, isolated infections or pathogen burden were not associated with the prevalence of atopic or nonatopic wheeze. Conclusion The findings provide support for the idea that the hygiene hypothesis is operating in an urban Latin American context, but its expression is thus far restricted to the atopic status of patients and not the perceived asthma symptoms.
Keywords: Atopy
Infections
Pathogen exposure
Allergen-specific IgE
Skin prick test
Wheezing illnesses
Asthma
metadata.dc.rights: Acesso Aberto
URI: http://repositorio.ufba.br/ri/handle/ri/15697
Issue Date: 2012
Appears in Collections:Artigo Publicado em Periódico (ICS)

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