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metadata.dc.type: | Artigo de Periódico |
Title: | Chemical composition and vasodilatation induced by Cuphea carthagenensis preparations |
Other Titles: | Phytomedicine |
Authors: | Krepsky, Patricia Baier Isidório, Raquel Geralda Souza Filho, José Dias de Côrtes, Steyner França Braga, Fernão Castro |
metadata.dc.creator: | Krepsky, Patricia Baier Isidório, Raquel Geralda Souza Filho, José Dias de Côrtes, Steyner França Braga, Fernão Castro |
Abstract: | The aerial parts of Cuphea carthagenensis (Jacq.) J.F. Macbride (Lythraceae) are traditionally employed in Brazil to treat cardiovascular diseases. The aim of this study was to compare preparations of C. carthagenensis aerial parts (aqueous and ethanol extracts, together with derived fractions) with regard to their total phenolic contents and in vitro vasodilating activity. The main flavonoids found in the extracts were isolated and identified as quercetin derivatives. The extracts and fractions showed similar HPLC profiles with the presence of quercetin-5-O-β-glucopyranoside, quercetin-3-O-α-arabinofuranoside and quercetin-3-sulfate in all of them, but marked differences in the contents of flavonoids, proanthocyanidins, tannis and total phenolics. Excepting the aqueous extract, all assayed preparations elicited vasodilatation on pre-contracted rat aortic rings in the range of pIC50 4.53 ± 0.03 to 4.98 ± 0.06. Polynomial regression analysis demonstrated the relationship between vasodilating activity and the contents of flavonoids (r2 = 0.5190), proanthocyanidins (r2 = 0.8016), tannins (r2 = 0.8041) and total phenolics (r2 = 0.6226), suggesting the participation of these compounds in the pharmacological effect and their potential use as chemical markers for the species. |
Keywords: | Cuphea carthagenensis Total phenolic contents Quercetin5-O-β-glucopyranoside Quercetin-3-O-α-arabinofuranoside Vasodilator effect |
metadata.dc.rights: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/15242 |
Issue Date: | 2012 |
Appears in Collections: | Artigo Publicado em Periódico (IMS) |
Files in This Item:
File | Description | Size | Format | |
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Patricia Baier Krepsky.pdf | 372,77 kB | Adobe PDF | View/Open |
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