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|Title: ||Treatment of strongyloidiasis in HTLV-1 and Strongyloides stercoralis coinfected patients is associated with increased TNFα and decreased soluble IL2 receptor levels|
|Other Titles: ||Transactions of The Royal Society of Tropical Medicine and Hygiene|
|Authors: ||Salles, Fernanda|
Sundberg, Michael A.
Santos, Silvane Maria Braga
Porto, Maria Aurélia da Fonseca
Carvalho Filho, Edgar Marcelino de
|Keywords: ||HTLV-1;Strongyloides stercoralis;Leukemia;ATLL;Interleukin-2 receptor;sIL-2R;Human T-lymphotropic virus 1;Leukemia-Lymphoma, Adult T-Cell|
|Issue Date: ||2013|
|Abstract: ||Background Human T cell lymphotropic virus type 1 (HTLV-1) infection has been associated with recurrent and disseminated strongyloidiasis and adult T cell leukemia/lymphoma (ATLL).
Methods We compared immunological aspects and markers for ATLL in HTLV-1 patients with or without strongyloidiasis, and evaluated the influence of Strongyloides stercoralis treatment on the immune response and clinical outcomes of HTLV-1 infection.
Results Levels of TNFα and IFNγ were lower in patients coinfected with HTLV-1 and S. stercoralis than in patients with HTLV-1 only (p < 0.05), and there was an increase in TNFα levels after anthelmintic treatment. Levels of sIL-2R were higher in patients with HTLV-1 coinfected with S. stercoralis and anthelmintic treatment decreased sIL-2R levels (p < 0.05). The one patient who developed ATLL was coinfected with S. stercoralis.
Conclusion These data show that helminthic infection has a modulatory role in HTLV-1 infection and that S. stercoralis may be a cofactor in the development of ATLL.|
|Description: ||Texto completo: acesso restrito. p. 526-529|
|Appears in Collections:||Artigos Publicados em Periódicos (Medicina)|
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