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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/15057

Title: Treatment of strongyloidiasis in HTLV-1 and Strongyloides stercoralis coinfected patients is associated with increased TNFα and decreased soluble IL2 receptor levels
Other Titles: Transactions of The Royal Society of Tropical Medicine and Hygiene
Authors: Salles, Fernanda
Bacellar, Andrea
Amorim, Mirla
Orge, Glória
Sundberg, Michael A.
Lima, Márcia
Santos, Silvane Maria Braga
Porto, Maria Aurélia da Fonseca
Carvalho Filho, Edgar Marcelino de
Keywords: HTLV-1;Strongyloides stercoralis;Leukemia;ATLL;Interleukin-2 receptor;sIL-2R;Human T-lymphotropic virus 1;Leukemia-Lymphoma, Adult T-Cell
Issue Date: 2013
Abstract: Background Human T cell lymphotropic virus type 1 (HTLV-1) infection has been associated with recurrent and disseminated strongyloidiasis and adult T cell leukemia/lymphoma (ATLL). Methods We compared immunological aspects and markers for ATLL in HTLV-1 patients with or without strongyloidiasis, and evaluated the influence of Strongyloides stercoralis treatment on the immune response and clinical outcomes of HTLV-1 infection. Results Levels of TNFα and IFNγ were lower in patients coinfected with HTLV-1 and S. stercoralis than in patients with HTLV-1 only (p < 0.05), and there was an increase in TNFα levels after anthelmintic treatment. Levels of sIL-2R were higher in patients with HTLV-1 coinfected with S. stercoralis and anthelmintic treatment decreased sIL-2R levels (p < 0.05). The one patient who developed ATLL was coinfected with S. stercoralis. Conclusion These data show that helminthic infection has a modulatory role in HTLV-1 infection and that S. stercoralis may be a cofactor in the development of ATLL.
Description: Texto completo: acesso restrito. p. 526-529
URI: http://repositorio.ufba.br/ri/handle/ri/15057
ISSN: 0035-9203
Appears in Collections:Artigos Publicados em Periódicos (Medicina)

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