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dc.contributor.authorSalles, Fernanda-
dc.contributor.authorBacellar, Andrea-
dc.contributor.authorAmorim, Mirla-
dc.contributor.authorOrge, Glória-
dc.contributor.authorSundberg, Michael A.-
dc.contributor.authorLima, Márcia-
dc.contributor.authorSantos, Silvane Maria Braga-
dc.contributor.authorPorto, Maria Aurélia da Fonseca-
dc.contributor.authorCarvalho Filho, Edgar Marcelino de-
dc.creatorSalles, Fernanda-
dc.creatorBacellar, Andrea-
dc.creatorAmorim, Mirla-
dc.creatorOrge, Glória-
dc.creatorSundberg, Michael A.-
dc.creatorLima, Márcia-
dc.creatorSantos, Silvane Maria Braga-
dc.creatorPorto, Maria Aurélia da Fonseca-
dc.creatorCarvalho Filho, Edgar Marcelino de-
dc.descriptionTexto completo: acesso restrito. p. 526-529pt_BR
dc.description.abstractBackground Human T cell lymphotropic virus type 1 (HTLV-1) infection has been associated with recurrent and disseminated strongyloidiasis and adult T cell leukemia/lymphoma (ATLL). Methods We compared immunological aspects and markers for ATLL in HTLV-1 patients with or without strongyloidiasis, and evaluated the influence of Strongyloides stercoralis treatment on the immune response and clinical outcomes of HTLV-1 infection. Results Levels of TNFα and IFNγ were lower in patients coinfected with HTLV-1 and S. stercoralis than in patients with HTLV-1 only (p < 0.05), and there was an increase in TNFα levels after anthelmintic treatment. Levels of sIL-2R were higher in patients with HTLV-1 coinfected with S. stercoralis and anthelmintic treatment decreased sIL-2R levels (p < 0.05). The one patient who developed ATLL was coinfected with S. stercoralis. Conclusion These data show that helminthic infection has a modulatory role in HTLV-1 infection and that S. stercoralis may be a cofactor in the development of ATLL.pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectStrongyloides stercoralispt_BR
dc.subjectInterleukin-2 receptorpt_BR
dc.subjectHuman T-lymphotropic virus 1pt_BR
dc.subjectLeukemia-Lymphoma, Adult T-Cellpt_BR
dc.titleTreatment of strongyloidiasis in HTLV-1 and Strongyloides stercoralis coinfected patients is associated with increased TNFα and decreased soluble IL2 receptor levelspt_BR
dc.title.alternativeTransactions of The Royal Society of Tropical Medicine and Hygienept_BR
dc.typeArtigo de Periódicopt_BR
dc.identifier.numberv. 107, n. 8pt_BR
Appears in Collections:Artigo Publicado em Periódico (Faculdade de Medicina)

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