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metadata.dc.type: | Artigo de Periódico |
Title: | Regeneration of critical bone defects with anionic collagen matrix as scaffolds |
Other Titles: | Journal of Materials Science: Materials in Medicine |
Authors: | Miguel, Fúlvio Borges Barbosa Júnior, Aryon de Almeida Paula, Fabiana Lopes de Barreto, Isabela Cerqueira Goissis, Gilberto Rosa, Fabiana Paim |
metadata.dc.creator: | Miguel, Fúlvio Borges Barbosa Júnior, Aryon de Almeida Paula, Fabiana Lopes de Barreto, Isabela Cerqueira Goissis, Gilberto Rosa, Fabiana Paim |
Abstract: | The aim of this study was to make a histomorphometric evaluation of the osteogenic potential of anionic collagen matrix as scaffolds; either crosslinked in glutaraldehyde or not cross-linked and, implanted in critical bone defects in rat calvaria. Seventy-two rats were randomly distributed in three groups: anionic collagen scaffolds treated for 24 h of selective hydrolysis (ACSH); anionic collagen scaffolds treated for 24 h of selective hydrolysis and 5 min of crosslinking in glutaraldehyde 0.05 % (ACSHGA); empty bone defect (Control), evaluated at the biological points of 15, 45, 90 and 120 days. The results showed that the biomaterials implanted were biocompatible and showed a high osteogenic potential. These biomaterials presented a speed of biodegradation compatible with bone neoformation, which was shown to be associated with angiogenesis inside the scaffolds at all biological points. The percentage of mineralization of ACSH (87 %) differed statistically from that found in ACSHGA (66 %). It was concluded that the regeneration of critical bone defect was more evident in anionic collagen without crosslinking (ACSH). |
metadata.dc.rights: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/14894 |
Issue Date: | 2013 |
Appears in Collections: | Artigo Publicado em Periódico (ICS) |
Files in This Item:
File | Description | Size | Format | |
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art%3A10.1007%2Fs10856-013-4980-8.pdf | 631,53 kB | Adobe PDF | View/Open |
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