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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/14891
Tipo: Artigo de Periódico
Título: Involvement of potassium channels in vasorelaxant effect induced by valeriana prionophylla Standl. in rat mesenteric artery
Título(s) alternativo(s): Evidence-Based Complementary and Alternative Medicine
Autor(es): Reis, Milena Ramos
Oliveira Filho, Abrahão Alves de
Rodrigues, Lilia Simone Urzedo
Araújo, Jaíse Paiva
Maciel, Priscilla Maria Pereira
Albuquerque, Jamile Morais de
Cehinel Filho, Valdir
Cáceres, Armando
Fregoneze, Josmara Bartolomei
Medeiros, Isac Almeida de
Silva, Darizy Flávia
Autor(es): Reis, Milena Ramos
Oliveira Filho, Abrahão Alves de
Rodrigues, Lilia Simone Urzedo
Araújo, Jaíse Paiva
Maciel, Priscilla Maria Pereira
Albuquerque, Jamile Morais de
Cehinel Filho, Valdir
Cáceres, Armando
Fregoneze, Josmara Bartolomei
Medeiros, Isac Almeida de
Silva, Darizy Flávia
Abstract: Assays in vitro and in vivo were performed on extract from roots and leaves from the Valeriana prionophylla Standl. (VPR and VPF, resp.). In phenylephrine (1 μM) precontracted rings, VPR (0.01–300 μg/mL) induced a concentration-dependent relaxation (maximum response (MR) = 75.4 ± 4.0%, EC50 = 5.97 (3.8–9.3) μg/mL, ]); this effect was significantly modified after removal of the endothelium (EC50 = 39.6 (27.2–57.6) μg/mL, ). However, VPF-induced vasorelaxation was less effective compared to VPR. When rings were preincubated with L-NAME (100 μM) or indomethacin (10 μM), the endothelium-dependent relaxation induced by VPR was significantly attenuated (MR = 20.9 ± 2.3%, 34.2 ± 2.9%, resp., ). In rings denuded endothelium, precontracted with KCl (80 mM), or in preparations pretreated with KCl (20 mM) or tetraethylammonium (1 or 3 mM), the vasorelaxant activity of VPR was significantly attenuated (MR = 40.0 ± 8.2, ; 50.5 ± 6.0%; 49.3 ± 6.4%; 46.8 ± 6.2%; resp., ). In contrast, neither glibenclamide (10 μM), barium chloride (30 μM), nor 4-aminopyridine (1 mM) affected VPR-induced relaxation. Taken together, these results demonstrate that hypotension induced by VPR seems to involve, at least in part, a vascular component. Furthermore, endothelium-independent relaxation induced by VPR involves K+ channels activation, most likely due to BKCa channels, in the rat superior mesenteric artery.
País: Brasil
Tipo de Acesso: Acesso Aberto
URI: http://repositorio.ufba.br/ri/handle/ri/14891
Data do documento: 2013
Aparece nas coleções:Artigo Publicado em Periódico (ICS)

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