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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/14551
Tipo: Artigo de Periódico
Título: The central amygdala regulates sodium intake in sodium-depleted rats: role of 5-HT3 and 5-HT2C receptors
Título(s) alternativo(s): Brain Research
Autor(es): Luz, C. P.
Souza, A.
Reis, R.
Mineiro, P.
Ferreira, Hilda Silva
Fregoneze, J. B.
Silva, E. De Castro e
Autor(es): Luz, C. P.
Souza, A.
Reis, R.
Mineiro, P.
Ferreira, Hilda Silva
Fregoneze, J. B.
Silva, E. De Castro e
Abstract: In the present paper, we have evaluated the participation of 5-HT3 and 5-HT2C receptors in the central amygdala (CeA) in the regulation of water and salt intake in sodium-depleted rats. m-CPBG-induced pharmacological activation of 5-HT3 receptors located in the CeA resulted in a significant reduction in salt intake in sodium-depleted rats. This antinatriorexic effect of m-CPBG was reverted by pretreatment with the selective 5-HT3 receptor antagonist ondansetron. The injection of ondansetron alone into the CeA had no effect on sodium-depleted and normonatremic rats. Conversely, pharmacological stimulation of 5-HT2C receptors located in the central amygdala by the selective 5-HT2C receptor agonist m-CPP failed to modify salt intake in sodium-depleted rats. Additionally, the administration of a selective 5-HT2C receptor blocker, SDZ SER 082, failed to modify salt intake in rats submitted to sodium depletion. These results lead to the conclusion that the pharmacological activation of 5-HT3 receptors located within the CeA inhibits salt intake in sodium-depleted rats and that 5-HT2C receptors located within the CeA appear to be dissociated from the salt intake control mechanisms operating in the central amygdala.
Palavras-chave: Serotonin
5HT2 receptor
5HT3 receptor
Salt intake
Water intake
Thirst
Amygdala
Central amygdala
Tipo de Acesso: Acesso Aberto
URI: http://repositorio.ufba.br/ri/handle/ri/14551
Data do documento: 2007
Aparece nas coleções:Artigo Publicado em Periódico (ICS)

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