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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/14282

Title: Helminthic Infection Down-Regulates Type 1 Immune Responses in Human T Cell Lymphotropic Virus Type 1 (HTLV-1) Carriers and Is More Prevalent in HTLV-1 Carriers than in Patients with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis
Other Titles: Journal of Infectious Diseases
Authors: Santos, Silvane Maria Braga
Rodrigues Junior, Waldyr
Muniz, André Luís Nunes
Basílio, Vanessa
Neva, Franklin A.
Dutra, Walderez Ornelas
Gollob, Kenneth John
Jacobson, Steven
Carvalho Filho, Edgar Marcelino de
Keywords: Human T-lymphotropic virus 1;CD4-Positive T-Lymphocytes;Myelitis;Paraparesis Tropical Spastic
Issue Date: 2005
Abstract: Human T cell lymphotropic virus type 1 (HTLV-1) infection is associated with an exacerbated type 1 immune response and secretion of high levels of proinflammatory cytokines. In contrast, helminthic infection induces a type 2 immune response. In the present study, the cytokine profile in HTLV-1 carriers coinfected with helminths (Strongyloides stercoralis and/or Schistosoma mansoni) was compared with that in HTLV-1 carriers not coinfected with helminths. Levels of interferon (IFN)-γ were higher in HTLV-1 carriers not coinfected with helminths than in HTLV-1 carriers coinfected with helminths (P < .05). The overall frequency of IFN-γ-expressing CD8+ and CD4+ cells was decreased in HTLV-1 carriers coinfected with helminths (P > .05). The percentage of interleukin (IL)-5- and IL-10-expressing T cells in HTLV-1 carriers coinfected with helminths was higher than that in HTLV-1 carriers not coinfected with helminths (P < .05). Moreover, we found that the prevalence of helminthic infection was 7-fold higher in HTLV-1 carriers than in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (P < .05). These data show that helminthic infection decreases activation of type 1 cells, which may influence the clinical outcome of HTLV-1 infection.
Description: Texto completo: acesso restrito. p. 612-618.
URI: http://repositorio.ufba.br/ri/handle/ri/14282
ISSN: 0022-1899,
Appears in Collections:Artigos Publicados em Periódicos (Medicina)

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