Campo DC | Valor | Idioma |
dc.contributor.author | Santos, Silvane Maria Braga | - |
dc.contributor.author | Rodrigues Junior, Waldyr | - |
dc.contributor.author | Muniz, André Luís Nunes | - |
dc.contributor.author | Basílio, Vanessa | - |
dc.contributor.author | Neva, Franklin A. | - |
dc.contributor.author | Dutra, Walderez Ornelas | - |
dc.contributor.author | Gollob, Kenneth John | - |
dc.contributor.author | Jacobson, Steven | - |
dc.contributor.author | Carvalho Filho, Edgar Marcelino de | - |
dc.creator | Santos, Silvane Maria Braga | - |
dc.creator | Rodrigues Junior, Waldyr | - |
dc.creator | Muniz, André Luís Nunes | - |
dc.creator | Basílio, Vanessa | - |
dc.creator | Neva, Franklin A. | - |
dc.creator | Dutra, Walderez Ornelas | - |
dc.creator | Gollob, Kenneth John | - |
dc.creator | Jacobson, Steven | - |
dc.creator | Carvalho Filho, Edgar Marcelino de | - |
dc.date.accessioned | 2014-01-07T13:33:33Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0022-1899, | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/14282 | - |
dc.description | Texto completo: acesso restrito. p. 612-618. | pt_BR |
dc.description.abstract | Human T cell lymphotropic virus type 1 (HTLV-1) infection is associated with an exacerbated type 1 immune response and secretion of high levels of proinflammatory cytokines. In contrast, helminthic infection induces a type 2 immune response. In the present study, the cytokine profile in HTLV-1 carriers coinfected with helminths (Strongyloides stercoralis and/or Schistosoma mansoni) was compared with that in HTLV-1 carriers not coinfected with helminths. Levels of interferon (IFN)-γ were higher in HTLV-1 carriers not coinfected with helminths than in HTLV-1 carriers coinfected with helminths (P < .05). The overall frequency of IFN-γ-expressing CD8+ and CD4+ cells was decreased in HTLV-1 carriers coinfected with helminths (P > .05). The percentage of interleukin (IL)-5- and IL-10-expressing T cells in HTLV-1 carriers coinfected with helminths was higher than that in HTLV-1 carriers not coinfected with helminths (P < .05). Moreover, we found that the prevalence of helminthic infection was 7-fold higher in HTLV-1 carriers than in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (P < .05). These data show that helminthic infection decreases activation of type 1 cells, which may influence the clinical outcome of HTLV-1 infection. | pt_BR |
dc.language.iso | en | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.source | http://dx.doi.org/ 10.1086/427560 | pt_BR |
dc.subject | Human T-lymphotropic virus 1 | pt_BR |
dc.subject | CD4-Positive T-Lymphocytes | pt_BR |
dc.subject | Myelitis | pt_BR |
dc.subject | Paraparesis Tropical Spastic | pt_BR |
dc.title | Helminthic Infection Down-Regulates Type 1 Immune Responses in Human T Cell Lymphotropic Virus Type 1 (HTLV-1) Carriers and Is More Prevalent in HTLV-1 Carriers than in Patients with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis | pt_BR |
dc.title.alternative | Journal of Infectious Diseases | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v.191, n. 4 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina)
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