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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/13764
Tipo: Artigo de Periódico
Título: Antibodies to citrullinated peptides in tuberculosis
Título(s) alternativo(s): Clinical Rheumatology
Autor(es): Lima, I.
Oliveira, R. C.
Atta, Ajax Mercês
Marchi, S.
Barbosa, L.
Reis, E.
Reis, M. G.
Santiago, Mittermayer Barreto
Autor(es): Lima, I.
Oliveira, R. C.
Atta, Ajax Mercês
Marchi, S.
Barbosa, L.
Reis, E.
Reis, M. G.
Santiago, Mittermayer Barreto
Abstract: Rheumatoid arthritis (RA) is an autoimmune disease characterized by symmetric polyarthritis, rheumatoid factor (RF) positivity, and bone erosions. Recently, research has been conducted on anti-citrullinated peptide antibodies (ACPAs) to which there are greater sensitivity and specificity than RF. However, these antibodies have also been described in infectious diseases, particularly tuberculosis (TB), placing the high specificity of the test in doubt. The aim of this research was to study the prevalence of ACPAs in TB, RA, and healthy controls. Patients with bacteriologically confirmed pulmonary tuberculosis, RA (ACR criteria), in addition to healthy controls were included. ACPAs were researched by: anti-cyclic citrullinated peptide (CCP), anti-modified citrullinated vimentin (MCV), and RF by ELISA. The study was conducted in 50 TB patients, 50 with RA, and 20 controls. Anti-CCP antibodies were found in 39 (78 %) of the RA patients (median titer, 128 U), whereas anti- MCV antibodies were found in 25 (50 %). Of the patients with TB, two (4 %) had positivity for anti- CCP and anti-MCV and no patient in the control group tested positive for these antibodies. Sensitivity of anti- CCP for RA was 78 % (confidence interval (CI), 63 to 88 %) and specificity was 97 % (CI, 89 to 99 %) while the sensitivity of anti-MCV was 50 % (CI, 35–64 %) and specificity was 97 % (CI, 89 to 99 %). RF was positive in 40 samples (80 %) of RA, in 30 (60 %) of TB, and in 1 (5 %) of the controls. Our findings showed high sensitivity of anti-CCP and high specificity of both anti-CCP and anti-MCV antibodies for RA, even in a population with high incidence of tuberculosis. The higher frequency of positivity of ACPA in TB observed in previous studies may be attributed to methodological factors.
Palavras-chave: ACPA
Anti-CCP
Anti-MCV
Rheumatoid arthritis
Rheumatoid factor
Tuberculosis
Editora / Evento / Instituição: Clinical Rheumatology
Tipo de Acesso: Acesso Aberto
URI: http://repositorio.ufba.br/ri/handle/ri/13764
Data do documento: 2013
Aparece nas coleções:Artigo Publicado em Periódico (Faculdade de Medicina)

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