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dc.contributor.authorLima, I.-
dc.contributor.authorOliveira, R. C.-
dc.contributor.authorAtta, Ajax Mercês-
dc.contributor.authorMarchi, S.-
dc.contributor.authorBarbosa, L.-
dc.contributor.authorReis, E.-
dc.contributor.authorReis, M. G.-
dc.contributor.authorSantiago, Mittermayer Barreto-
dc.creatorLima, I.-
dc.creatorOliveira, R. C.-
dc.creatorAtta, Ajax Mercês-
dc.creatorMarchi, S.-
dc.creatorBarbosa, L.-
dc.creatorReis, E.-
dc.creatorReis, M. G.-
dc.creatorSantiago, Mittermayer Barreto-
dc.date.accessioned2013-11-19T20:13:38Z-
dc.date.issued2013-
dc.identifier.issn0770-3198-
dc.identifier.urihttp://repositorio.ufba.br/ri/handle/ri/13764-
dc.descriptionp. 685-687pt_BR
dc.description.abstractRheumatoid arthritis (RA) is an autoimmune disease characterized by symmetric polyarthritis, rheumatoid factor (RF) positivity, and bone erosions. Recently, research has been conducted on anti-citrullinated peptide antibodies (ACPAs) to which there are greater sensitivity and specificity than RF. However, these antibodies have also been described in infectious diseases, particularly tuberculosis (TB), placing the high specificity of the test in doubt. The aim of this research was to study the prevalence of ACPAs in TB, RA, and healthy controls. Patients with bacteriologically confirmed pulmonary tuberculosis, RA (ACR criteria), in addition to healthy controls were included. ACPAs were researched by: anti-cyclic citrullinated peptide (CCP), anti-modified citrullinated vimentin (MCV), and RF by ELISA. The study was conducted in 50 TB patients, 50 with RA, and 20 controls. Anti-CCP antibodies were found in 39 (78 %) of the RA patients (median titer, 128 U), whereas anti- MCV antibodies were found in 25 (50 %). Of the patients with TB, two (4 %) had positivity for anti- CCP and anti-MCV and no patient in the control group tested positive for these antibodies. Sensitivity of anti- CCP for RA was 78 % (confidence interval (CI), 63 to 88 %) and specificity was 97 % (CI, 89 to 99 %) while the sensitivity of anti-MCV was 50 % (CI, 35–64 %) and specificity was 97 % (CI, 89 to 99 %). RF was positive in 40 samples (80 %) of RA, in 30 (60 %) of TB, and in 1 (5 %) of the controls. Our findings showed high sensitivity of anti-CCP and high specificity of both anti-CCP and anti-MCV antibodies for RA, even in a population with high incidence of tuberculosis. The higher frequency of positivity of ACPA in TB observed in previous studies may be attributed to methodological factors.pt_BR
dc.language.isoenpt_BR
dc.publisherClinical Rheumatologypt_BR
dc.rightsAcesso Abertopt_BR
dc.sourcehttp://download.springer.com/static/pdf/996/art%253A10.1007%252Fs10067-013-2173-y.pdf?auth66=1385057075_02d34faf15bf1d6cfba013499c3900e0&ext=.pdfpt_BR
dc.subjectACPApt_BR
dc.subjectAnti-CCPpt_BR
dc.subjectAnti-MCVpt_BR
dc.subjectRheumatoid arthritispt_BR
dc.subjectRheumatoid factorpt_BR
dc.subjectTuberculosispt_BR
dc.titleAntibodies to citrullinated peptides in tuberculosispt_BR
dc.title.alternativeClinical Rheumatologypt_BR
dc.typeArtigo de Periódicopt_BR
dc.description.localpubSalvadorpt_BR
dc.identifier.numberv. 32, n. 5pt_BR
dc.embargo.liftdate10000-01-01-
Aparece nas coleções:Artigo Publicado em Periódico (Faculdade de Medicina)

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