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https://repositorio.ufba.br/handle/ri/13667
metadata.dc.type: | Artigo de Periódico |
Título : | The −2518 bp promoter polymorphism at CCL2/MCP1 influences susceptibility to mucosal but not localized cutaneous leishmaniasis in Brazil |
Otros títulos : | Infection, Genetics and Evolution |
Autor : | Ramasawmy, Rajendranath Menezes, Eliane Magalhães, Andrea Oliveira, Joyce Castellucci, Léa Almeida, Roque Pacheco de Rosa, Maria Elisa Alves Guimarães, Luiz Henrique Lessa, Marcus Carvalho Filho, Edgar Marcelino de Jesus, Amélia Ribeiro de |
metadata.dc.creator: | Ramasawmy, Rajendranath Menezes, Eliane Magalhães, Andrea Oliveira, Joyce Castellucci, Léa Almeida, Roque Pacheco de Rosa, Maria Elisa Alves Guimarães, Luiz Henrique Lessa, Marcus Carvalho Filho, Edgar Marcelino de Jesus, Amélia Ribeiro de |
Resumen : | Mucosal leishmaniasis (ML) follows localized cutaneous leishmaniasis (CL) caused by Leishmania braziliensis. Proinflammatory responses mediate CL self-healing but are exaggerated in ML. Proinflammatory monocyte chemoattractant protein 1 (MCP-1; encoded by CCL2) is associated with CL. We explore its role in CL/ML through analysis of the regulatory CCL2 −2518 bp promoter polymorphism in CL/ML population samples and families from Brazil. Genotype frequencies were compared among ML/CL cases and control groups using logistic regression and the family-based association test (FBAT). MCP-1 was measured in plasma and macrophages. The GG recessive genotype at CCL2 −2518 bp was more common in patients with ML (N = 67) than in neighborhood control (NC; N = 60) subjects (OR 1.78; 95% CI 1.01–3.14; P = 0.045), than in NC combined with leishmanin skin-test positive (N = 60) controls (OR 4.40; 95% CI 1.42–13.65; P = 0.010), and than in controls combined with CL (N = 60) patients (OR 2.78; 95% CI 1.13–6.85; P = 0.045). No associations were observed for CL compared to any groups. FBAT (91 ML and 223 CL cases in families) confirmed recessive association of ML with allele G (Z = 2.679; P = 0.007). Higher levels of MCP-1 occurred in plasma (P = 0.03) and macrophages (P < 0.0001) from GG compared to AA individuals. These results suggest that high MCP-1 increases risk of ML. |
Palabras clave : | Mucosal leishmaniasis Genetic association MCP-1 CCL2 |
metadata.dc.rights: | Acesso Aberto |
URI : | http://repositorio.ufba.br/ri/handle/ri/13667 |
Fecha de publicación : | 2010 |
Aparece en las colecciones: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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1-s2.0-S1567134810001048-main.pdf | 185,71 kB | Adobe PDF | Visualizar/Abrir |
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