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https://repositorio.ufba.br/handle/ri/12792
metadata.dc.type: | Artigo de Periódico |
Title: | Neospora caninum: Infection induced IL-10 overexpression in rat astrocytes in vitro |
Other Titles: | Experimental Parasitology |
Authors: | Pinheiro, A. M. Costa, Silvia Lima Freire, S. M. Nascimento, Roberto José Meyer Almeida, Maria Angela Ornelas de Tardy, Marcienne Bloch El-Bachá, Ramon dos Santos Costa, Maria de Fátima Dias |
metadata.dc.creator: | Pinheiro, A. M. Costa, Silvia Lima Freire, S. M. Nascimento, Roberto José Meyer Almeida, Maria Angela Ornelas de Tardy, Marcienne Bloch El-Bachá, Ramon dos Santos Costa, Maria de Fátima Dias |
Abstract: | The effect of Neospora caninum, a parasite that causes abortion and neuromuscular changes, has been investigated on a major population of neural cells, the astrocytes. Highly enriched astroglial primary cultures obtained from neonatal rats were infected after 21 days of culture. Astroglial reactivity, IL-10 and IFN-γ expression, and cell viability (lactate dehydrogenase activity, metabolization of tetrazolium salt, and trypan blue exclusion assay) have been investigated after 24 and 72 h of infection. Astroglial hypertrophy, gliofilament reorganization, metabolic changes suggesting hypoxia and a strong IL-10 release have been observed in the infected cells. These results show that neural cells are targets for the parasite and that astrocytes may contribute to the CNS immune response to the parasite. |
Keywords: | Neospora caninum Astrocytes Immune response |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/12792 |
Issue Date: | 2006 |
Appears in Collections: | Artigo Publicado em Periódico (ICS) |
Files in This Item:
File | Description | Size | Format | |
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1-s2.0-S0014489405002791-main.pdf Restricted Access | 294,48 kB | Adobe PDF | View/Open Request a copy |
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