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metadata.dc.type: | Artigo de Periódico |
Title: | Granulocyte-macrophage colony-stimulating factor in combination with pentavalent antimony for the treatment of visceral leishmaniasis |
Other Titles: | European Journal of Clinical Microbiology and Infectious Diseases |
Authors: | Badaró, Roberto José da Silva Nascimento, C. Carvalho, Jozélio Freire de Badaró, F. Russo, D. Ho, J. L. Reed, Steven G. Johnson Junior, W. D. Jones, T. C. |
metadata.dc.creator: | Badaró, Roberto José da Silva Nascimento, C. Carvalho, Jozélio Freire de Badaró, F. Russo, D. Ho, J. L. Reed, Steven G. Johnson Junior, W. D. Jones, T. C. |
Abstract: | The efficacy of GM-CSF was investigated in 20 neutropenic patients (< 1500 neutrophils/µl) with acute visceral leishmaniasis due toLeishmania chagasi. Patients were randomized to receive either GM-CSF, 5 µg/kg daily (intravenously or subcutaneously), or placebo for ten days, in combination with pentavalent antimony, 10–20 mg/kg daily for 20 days. Neutrophil counts were significantly greater on days 5 and 10 of treatment in the GM-CSF group compared with the placebo group (p<0.02). Eosinophil and monocyte counts were also significantly increased in the GM-CSF group at day 10 (p≤0.03). Interestingly, at day 30, platelet counts were significantly higher in the GM-CSF treated group (p=0.007). Haemoglobin levels were significantly increased in the GM-CSF group on days 5 and 10 (p=0.04 and 0.02, respectively). Patients in the GM-CSF group experienced fewer secondary bacterial or viral infections than placebo patients. Infections occurred in only three patients given GM-CSF compared with eight patients given placebo (p<0.04). All patients had complete resolution of disease symptoms at three months. Few adverse events were recorded. GM-CSF given subcutaneously at a dose of 5 µg/kg daily for ten days was well tolerated, reversed neutropenia rapidly and reduced the number of secondary infections in patients with leishmaniasis. |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/8753 |
Issue Date: | 1994 |
Appears in Collections: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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Badaro.pdf Restricted Access | 778,61 kB | Adobe PDF | View/Open Request a copy |
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