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https://repositorio.ufba.br/handle/ri/8717
Tipo: | Artigo de Periódico |
Título: | Leishmania mexicana: Immunology and histopathology in C3H mice |
Título(s) alternativo(s): | Experimental Parasitology |
Autor(es): | Grimaldi Jr., Gabriel Moriearty, Pamela Lane |
Autor(es): | Grimaldi Jr., Gabriel Moriearty, Pamela Lane |
Abstract: | Leishmania mexicana: Immunology and histopathology in C3H mice. Experimental Parasitology 50, 45-56. C3H mice were infected subcutaneously with lo5 promastigotes of Leishmania mexicana and subsequent lesions were examined at 3, 5, and 8 months. All animals developed persistent nonulcerating nodules of variable size which did not metastasize. The nodules contained amastigotes with a mononuclear infiltrate of histiocytes, lymphocytes, and plasma cells, but without formation of tuberculoid-type granulomas. Neutrophils and eosinophils were also encountered in some cases. Specific antileishmanial antibodies and delayed-type hypersensitivity to leishmanial antigen were present at 3, 5, and 8 months postinfection. L. mexicana infection in C3H mice differs from classic self-healing cutaneous leishmaniasis by the persistence of nonhealing, nonulcerating, nonmetastasizing lesions, despite evidence of cellular and humoral immunity. |
Palavras-chave: | Leishmania mexicana Protozoa parasitic Hemoflagellate Mice C3H Leishmaniasis cutaneous Immunofluorescence Indirect hemagglutination Delayed hypersensitivity Ear thickness test Histopathology |
Editora / Evento / Instituição: | Experimental Parasitology |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/8717 |
Data do documento: | 1980 |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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