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https://repositorio.ufba.br/handle/ri/8345
metadata.dc.type: | Artigo de Periódico |
Título : | Clinical and immunological consequences of human T cell leukemia virus type-I and Schistosoma mansoni co-infection |
Otros títulos : | Memórias do Instituto Oswaldo Cruz |
Autor : | Santos, Silvane Maria Braga Porto, Maria Aurélia da Fonseca Muniz, André Luís Nunes Jesus, Amélia Ribeiro de Carvalho Filho, Edgar Marcelino de |
metadata.dc.creator: | Santos, Silvane Maria Braga Porto, Maria Aurélia da Fonseca Muniz, André Luís Nunes Jesus, Amélia Ribeiro de Carvalho Filho, Edgar Marcelino de |
Resumen : | Human T cell leukemia virus type-I (HTLV-I) infection is associated with spontaneous T cell activation and uncontrolled lymphocyte proliferation. An exacerbated type-1 immune response with production of pro-inflammatory cytokines (interferon-g and tumor necrosis factor-a) is significantly higher in patients with myelopathy associated to HTLV-I than in HTLV-I asymptomatic carriers. In contrast with HTLV-I, a chronic Schistosoma mansoni infection is associated with a type-2 immune response with high levels of interleukin (IL-4, IL-5, and IL-10) and low levels of IFN-g. In this study, clinical and immunological consequences of the HTLV-I and S. mansoni infection were evaluated. The immune response in patients with schistosomiasis co-infected with HTLV-I showed low levels of IL-5 (p < 0.05) in peripheral blood mononuclear cells cultures stimulated with S. mansoni antigen (SWAP) and decreased SWAP-specific IgE levels when compared with patients with only schistosomiasis (p < 0.05). Liver fibrosis was mild in all HTLV-I co-infected patients. Immunological response was also compared in individuals who had only HTLV-I infection with those who were co-infected with HTLV-I and helminths (S. mansoni and Strongyloides stercoralis). In patients HTLV-I positive co-infected with helminths the IFN-g levels were lower than in individuals who had only HTLV-I. Moreover, there were fewer cells expressing IFN-g and more cells expressing IL-10 in individuals co-infected with HTLV-I and helminths. These dates indicate that HTLV-I infection decrease type 2-response and IgE synthesis and are inversely associated with the development of liver fibrosis. Moreover, helminths may protect HTLV-I infected patients to produce large quantities of pro-inflammatory cytokines such as IFN-g. |
Palabras clave : | human T cell leukemia virus type-1 Schistoma mansoni co-infection |
URI : | http://www.repositorio.ufba.br/ri/handle/ri/8345 |
Fecha de publicación : | 2004 |
Aparece en las colecciones: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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