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metadata.dc.type: | Artigo de Periódico |
Title: | Self-inhibiting action of nortriptyline's anti-immobility effect at high plasma and brain levels in mice |
Other Titles: | Psychopharmacology |
Authors: | Oliveira, Irismar Reis de Diquet, Bertrand Meersch, Véronique Van der Dardennes, Roland Gonidec, Jean Lima, Pedro Antônio do Prado de |
metadata.dc.creator: | Oliveira, Irismar Reis de Diquet, Bertrand Meersch, Véronique Van der Dardennes, Roland Gonidec, Jean Lima, Pedro Antônio do Prado de |
Abstract: | Animals were treated acutely with 0, 2.5, 5, 10, 20 and 40 mg/kg nortriptyline (NT) 30 rain before the tail suspension test (TST). They were sacrificed after test for evaluation of plasma and brain levels of NT. The antiimmobility effect increased with increasing doses and concentrations of the drug, reaching statistical significance (P<0.01, Dunnett test) at a dose of 20 mg/kg, 865 ng/ml in plasma and I1 gg/g in brain tissue. The anti-immobility effect was, however, blocked with the highest, non-toxic, concentrations. Results seem to indicate a biphasic curvilinear relationship between plasma and brain levels of NT and behaviour in mice. |
Keywords: | Nortriptyline Plasma levels Brain levels Tail suspension test Mice |
Publisher: | Psychopharmacology |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/7868 |
Issue Date: | 1990 |
Appears in Collections: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Files in This Item:
File | Description | Size | Format | |
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EEEEEEEE15125.pdf | 435,53 kB | Adobe PDF | View/Open |
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