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https://repositorio.ufba.br/handle/ri/7749
metadata.dc.type: | Artigo de Periódico |
Title: | Lutzomyia longipalpis Salivary Gland Homogenate Impairs Cytokine Production and Costimulatory Molecule Expression on Human Monocytes and Dendritic Cells |
Other Titles: | Infection and Immunity |
Authors: | Costa, Dirceu Joaquim Favali, Cecilia Beatriz Fiuza Andrade, Jorge Clarencio Souza Macêdo, Lilian Maria Afonso de Conceição, Viviane Nascimento da Miranda, José Carlos |
metadata.dc.creator: | Costa, Dirceu Joaquim Favali, Cecilia Beatriz Fiuza Andrade, Jorge Clarencio Souza Macêdo, Lilian Maria Afonso de Conceição, Viviane Nascimento da Miranda, José Carlos |
Abstract: | In this report, we describe an investigation of the effects of Lutzomyia longipalpis sand fly salivary gland homogenates (SGH) on cytokine production and expression of costimulatory molecules on human monocytes, macrophages (Mφs), and dendritic cells (DCs). SGH of L. longipalpis induced an increase in interleukin-6 (IL-6), IL-8 and IL-12p40 production but a decrease in tumor necrosis factor alpha and IL-10 production by lipopolysaccharida (LPS)-stimulated monocytes. We also examined the expression of costimulatory molecules on the surface of monocytes, Mφs, and DCs. Whereas SGH affected the expression of these molecules on monocytes and Mφs, it had little effect on these molecules on DCs. However, when DCs were generated from human monocytes in the presence of SGH, SGH inhibited the expression of costimulatory molecules. In addition, a decrease in the maturation of DCs induced by CD40L was observed in the presence of SGH. Finally, preincubating SGH with human sera containing anti-SGH-specific antibodies abolished the effects of SGH on cytokine production by LPS-stimulated monocytes. |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/7749 |
Issue Date: | 2004 |
Appears in Collections: | Artigo Publicado em Periódico (ICS) |
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