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https://repositorio.ufba.br/handle/ri/7467| metadata.dc.type: | Artigo de Periódico |
| Title: | Prevalence of the CCR5Δ32 mutation in Brazilian populations and cell susceptibility to HIV-1 infection |
| Other Titles: | Human Genetics |
| Authors: | Grimaldi, Rogério Shindo, Nice Acosta, Angelina Xavier Dourado, Maria Inês Costa Brites, Carlos Bou-Habib, Dumith Chequer Castro, Bernardo Galvão Carvalho, Ozenilda de Melo Brito, Ivo |
| metadata.dc.creator: | Grimaldi, Rogério Shindo, Nice Acosta, Angelina Xavier Dourado, Maria Inês Costa Brites, Carlos Bou-Habib, Dumith Chequer Castro, Bernardo Galvão Carvalho, Ozenilda de Melo Brito, Ivo |
| Abstract: | We investigated the occurrence of the CCR5Δ32 mutation in various regional ethnic groups in Brazil and tested the resistance of mutant peripheral blood mononuclear cells (PBMCs) to infection by HIV-1 in vitro. The heterozygous prevalence was 5.3% in uninfected African descendents and 8.8% in HIV-1-positive individuals (neither population had Δ32/Δ32). German descendents were 11% heterozygous and l% Δ32/Δ32. Amerindians were exclusively CCR5/CCR5. Heterozygous uninfected PBMCs showed partial resistance to R5-HIV-1 strains in vitro, but no resistance to X4 virus. HIV-1-positive CCR5/CCR5 had higher viral loads than did heterozygous cells. |
| URI: | http://www.repositorio.ufba.br/ri/handle/ri/7467 |
| Issue Date: | Jul-2002 |
| Appears in Collections: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| art%253A10.1007%252Fs00439-002-0747-x.pdf Restricted Access | 40,65 kB | Adobe PDF | View/Open Request a copy |
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