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metadata.dc.type: | Artigo de Periódico |
Title: | B-cell infiltration and frequency of cytokine producing cells differ between localized and disseminated human cutaneous leishmaniases |
Other Titles: | Memórias do Instituto Oswaldo Cruz |
Authors: | Vieira, M. G. S. Oliveira, F. Arruda, Sérgio Marcos Bittencourt, Achilea Candida Lisboa Barbosa Júnior, Aryon de Almeida Barral-Netto, Manoel Barral, Aldina Maria Prado |
metadata.dc.creator: | Vieira, M. G. S. Oliveira, F. Arruda, Sérgio Marcos Bittencourt, Achilea Candida Lisboa Barbosa Júnior, Aryon de Almeida Barral-Netto, Manoel Barral, Aldina Maria Prado |
Abstract: | Biopsies from human localized cutaneous lesions (LCL n = 7) or disseminated lesions (DL n = 8) cases were characterized according to cellular infiltration,frequency of cytokine (IFN-y, TNF-a) or iNOS enzyme producing cells. LCL, the most usual form of the disease with usually one or two lesions, exhibits extensive tissue damage. DL is a rare form with widespread lesions throughout the body; exhibiting poor parasite containment but less tissue damage. We demonstrated that LCL lesions exhibit higher frequency of B lymphocytes and a higher intensity of IFN-y expression. In both forms of the disease CD8+ were found in higher frequency than CD4+ T cells. Frequency of TNF-a and iNOS producing cells, as well as the frequency of CD68+ macrophages, did not differ between LCL and DL. Our findings reinforce the link between an efficient control of parasite and tissue damage, implicating higher frequency of IFN-y producing cells, as well as its possible counteraction by infiltrated B cells and hence possible humoral immune response in situ. |
Keywords: | leishmaniasis B lymphocytes cytokines CD8+ T cells IFN-y |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/7458 |
Issue Date: | Oct-2002 |
Appears in Collections: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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