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https://repositorio.ufba.br/handle/ri/7398
metadata.dc.type: | Artigo de Periódico |
Title: | Leishmania amazonensis infection: A comparison of in vivo leishmanicidal mechanisms between immunized and naive infected BALB/c mice |
Other Titles: | Experimental Parasitology |
Authors: | Pompeu, M. L. Freitas, L. A. Santos, M. L. V. Barral, Aldina Maria Prado Barral-Netto, Manoel |
metadata.dc.creator: | Pompeu, M. L. Freitas, L. A. Santos, M. L. V. Barral, Aldina Maria Prado Barral-Netto, Manoel |
Abstract: | In vitro studies have shown that both macrophage activation and destruction of parasitized macrophages lead to leishmania destruction. The relative role played by such mechanisms in vivo have not been properly evaluated. We took advantage of the model of intravenous immunization with solubilized leishmanial antigen which renders partially resistant the otherwise highly susceptible BALB/c mice to address this issue avoiding the interference of different genetic backgrounds. Leishmania destruction occurred in three situations: destruction of the parasitized macrophage, which were in close contact with lymphocytes or eosinophils; extracellular damage, always surrounded by small foci of granulocytes; and parasite damage inside activated macrophages. Destruction of the parasitized macrophages was frequently seen in immunized and protected animals. Our observations suggest that destruction of parasite-loaded macrophages is an important mechanism of host protection in experimental cutaneous leishmaniasis. |
Keywords: | Leishmania amazonensis Leishmaniasis Immunization Leishmania Tegumentary leishmaniasis |
Publisher: | Experimental Parasitology |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/7398 |
Issue Date: | 1992 |
Appears in Collections: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Files in This Item:
File | Description | Size | Format | |
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fffff9999.pdf | 3,23 MB | Adobe PDF | View/Open |
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