Vascular endothelial growth factor (VEGF) levels as a tool to discriminate between malignant and nonmalignant ascites

Please use this identifier to cite or link to this item: https://repositorio.ufba.br/handle/ri/7149

metadata.dc.type:	Artigo de Periódico
Title:	Vascular endothelial growth factor (VEGF) levels as a tool to discriminate between malignant and nonmalignant ascites
Other Titles:	APMIS
Authors:	Nascimento, Ivana Lúcia de Oliveira Schaer, Robert Eduard Lemaire, Denise Carneiro Freire, S. Paule, B. Carvalho, Sabrina Nascimento, Roberto José Meyer Schaer-Barbosa, Helenemarie
metadata.dc.creator:	Nascimento, Ivana Lúcia de Oliveira Schaer, Robert Eduard Lemaire, Denise Carneiro Freire, S. Paule, B. Carvalho, Sabrina Nascimento, Roberto José Meyer Schaer-Barbosa, Helenemarie
Abstract:	Ascites formation is commonly associated with cancer, although it is also present in other diseases.The aim of this study was to evaluate the usefulness of vascular endothelial growth factor as a malignancy marker in ascites of different etiologies. The levels of VEGF in 32 malignant and in 31 nonmalignant ascites were determined by enzyme immunoassay (ELISA). VEGF levels were significantly higher in malignant than in non-malignant ascites (medianΩ1265.9 pg/ml¿114.6 pg/ml; p 0.0001).We observed 72% sensitivity and 90% specificity, using 662 pg/ml as a cut-off value. Therefore, this approach can be used as a marker for a first screening to discriminate between malignant and nonmalignantascites.
Keywords:	VEGF angiogenesis ascites diagnosis
URI:	http://www.repositorio.ufba.br/ri/handle/ri/7149
Issue Date:	2004
Appears in Collections:	Artigo Publicado em Periódico (ICS)

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