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metadata.dc.type: | Artigo de Periódico |
Título : | The effect of single and multiple infections on atopy and wheezing in children |
Otros títulos : | J Allergy Clin Immunol |
Autor : | Neves, Neuza Maria Alcântara Veiga, Rafael Valente Dattoli, Vitor Camilo Cavalcante Fiaccone, Rosimeire Leovigildo Esquivel, Renata Cruz Filho, Álvaro Augusto Souza da Cooper, Philip John Rodrigues, Laura Cunha Barreto, Mauricio Lima |
metadata.dc.creator: | Neves, Neuza Maria Alcântara Veiga, Rafael Valente Dattoli, Vitor Camilo Cavalcante Fiaccone, Rosimeire Leovigildo Esquivel, Renata Cruz Filho, Álvaro Augusto Souza da Cooper, Philip John Rodrigues, Laura Cunha Barreto, Mauricio Lima |
Resumen : | Background: The current epidemic of asthma and atopy has been explained by alterations in immune responses related to reduction in childhood infections. However, the findings of epidemiologic studies investigating the association between infection with atopy and asthma have been inconsistent. Objective: We sought to investigate the effect of single or multiple infections (pathogen burden) on atopy and wheeze in urban children from Latin America. Methods: Specific IgE against aeroallergens (sIgE) and skin prick test (SPT) reactivity for the most common local allergens were measured in 1128 children aged 4 to 11 years. Data on wheezing and potential confounders were collected by questionnaire. Infections by 8 pathogens were assessed by using serology and stool examination. Associations of wheeze and atopic outcomes with single and multiple infections were analyzed by means of logistic regression. Results: Negative results for Toxoplasma gondii were associated with a higher prevalence of sIgE (>0.70 kU/L), whereas negative results for Ascaris lumbricoides, T gondii, erpes simplex virus, and EV were associated with a higher prevalence of SPT reactivity. Children with 3 or fewer infection markers had a higher prevalence of sIgE and SPT rectivity compared with those with 4 or more infection markers. However, isolated infections or pathogen burden were not associated with the prevalence of atopic or nonatopic wheeze. Conclusion: The findings provide support for the idea that the hygiene hypothesis is operating in an urban Latin American context, but its expression is thus far restricted to the atopic status of patients and not the perceived asthma symptoms. |
Palabras clave : | Atopy Infections Pathogen Exposure Allergen-specific IgE Asthma Wheezing Illnesses |
Editorial : | Elsevier |
URI : | http://www.repositorio.ufba.br/ri/handle/ri/7080 |
Fecha de publicación : | feb-2012 |
Aparece en las colecciones: | Artigo Publicado em Periódico Estrangeiro (ISC) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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The efect Per Intern 2012.pdf | 148,36 kB | Adobe PDF | Visualizar/Abrir |
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