Please use this identifier to cite or link to this item: https://repositorio.ufba.br/handle/ri/6699
metadata.dc.type: Artigo de Periódico
Title: Smooth muscle antibodies and cryoglobulinemia are associated with advanced liver fibrosis in Brazilian hepatitis C virus carriers
Other Titles: Brazilian Journal of Infectious Diseases
Authors: Andrade, Luis Jesuino de Oliveira
Melo, Paulo Roberto Santana de
Atta, Ajax Mercês
Atta, Maria Luiza Brito de Sousa
Jesus, Larissa Santana de
Sousa, Gabriel Menezes de
Silva, Carolina Alves Costa
Paraná, Raymundo
metadata.dc.creator: Andrade, Luis Jesuino de Oliveira
Melo, Paulo Roberto Santana de
Atta, Ajax Mercês
Atta, Maria Luiza Brito de Sousa
Jesus, Larissa Santana de
Sousa, Gabriel Menezes de
Silva, Carolina Alves Costa
Paraná, Raymundo
Abstract: Cryoglobulinemia and non-organ-specific-autoantibody are biomarkers of autoimmunity of the chronic infection caused by hepatitis C virus (HCV). In this work, we report the association between the presence of smooth muscle antibodies (SMA) and cryoglobulinemia and chronic liver disease in HCV carriers. Sixty-five untreated HCV patients, 38 women and 27 men were included in this study. Cryoglobulinemia was tested by cryoprecipitation, SMA by indirect fluorescent antibody test, and liver fibrosis and hepatocellular inflammation activity was investigated by histology of liver biopsy using the METAVIR score. The prevalence of SMA in the patients was 33.8% and cryoglobulinemia was demonstrated in 36.9% patients. Cryoglobulinemia and SMA seropositivity was associated with advanced fibrosis (p < 0.05). The presence of SMA and cryoglobulinemia was not associated with hepatocellular inflammation activity, age, carrier gender or HCV genotype. We concluded that liver biopsy should be recommended for HCV carriers that are seropositive for SMA or cryoglobulinemia.
Keywords: Hepatitis C
Muscle
Smooth
Antibody specificity
Cryoglobulins
Liver diseases
Publisher: The Brazilian Journal of Infectious Diseases and Contexto Publishing
URI: http://www.repositorio.ufba.br/ri/handle/ri/6699
Issue Date: Jan-2011
Appears in Collections:Artigo Publicado em Periódico (Faculdade de Medicina)

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