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https://repositorio.ufba.br/handle/ri/6585
metadata.dc.type: | Artigo de Periódico |
Title: | Skin reactivity to aeroallergens is reduced in human T-lymphotropic virus type I-infected healthy blood-donors (asymptomatic carriers) |
Other Titles: | Allergy |
Authors: | Machado, Adelmir de Souza Galvão, T. S. Porto, Maria Aurélia da Fonseca Figueiredo, J. Cruz Filho, Álvaro Augusto Souza da |
metadata.dc.creator: | Machado, Adelmir de Souza Galvão, T. S. Porto, Maria Aurélia da Fonseca Figueiredo, J. Cruz Filho, Álvaro Augusto Souza da |
Abstract: | Background: A type 2 immune response, characterized by high levels of interleukin-4 and immunoglobulin E synthesis is a hallmark of respiratory allergic diseases. Individuals infected with human T-lymphotropic virus type I (HTLV-I) virus have spontaneous T-cell proliferation and increased interferon γ production, which are immunological functions associated with a type 1 immune response. Objective: To determine the frequency of asthma and rhinitis symptoms and immediate skin reactivity to aeroallergens in HTLV-I infected individuals, compared with noninfected subjects. Methods: Cross sectional study of 101 HTLV-I infected and 101 control uninfected blood donors, assessed by enzyme-linked immunosorbent assay and Western blot assays. The subjects were age and sex-matched, identified as presenting allergy history by questionnaire, which was complemented by a complete clinical examination and skin prick tests for aeroallergens. Results: The frequency of atopy was lower in infected than uninfected subjects, 14.9 and 29.7% (P = 0.017), respectively. Skin reactivity to Dermatophagoides pteronissynus, Dermatophagoides farinae and Blomia tropicalis were the most frequently observed among all the tested antigens in both groups. Skin reactivity to histamine was also reduced in the infected individuals compared with uninfected subjects (medians 4.0 vs 5.0, respectively; P < 0.0001). Infection by HTLV-I was found to be a factor of protection to atopy (RP 0.44; P = 0.005). Conclusions: The HTLV-I infection reduces the frequency of respiratory allergy and skin reactivity to aeroallergens. |
Keywords: | allergy asthma atopy human T-lymphotropic virus type I retrovirus rhinitis |
Publisher: | John Wiley and Sons |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/6585 |
Issue Date: | 2005 |
Appears in Collections: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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