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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/6567
Tipo: Artigo de Periódico
Título: Femoral head necrosis treatment with autologous stem cells in sickle cell disease
Título(s) alternativo(s): Acta Ortopédica Brasileira
Autor(es): Daltro, Gildásio de Cerqueira
Fortuna, Vitor Antonio
Araújo, Marco Aurélio Salvino de
Lessa, Paulo Itamar Ferraz
Batista Sobrinho, Uirassú de Assis
Borojevic, Radovan
Autor(es): Daltro, Gildásio de Cerqueira
Fortuna, Vitor Antonio
Araújo, Marco Aurélio Salvino de
Lessa, Paulo Itamar Ferraz
Batista Sobrinho, Uirassú de Assis
Borojevic, Radovan
Abstract: PURPOSE: To assess the efficacy and safety of autologous bone-marrow mononuclear cells (BMMC) implantation in necrotic lesions of the femoral head in patients with sickle cell disease. METHODS: We studied eight patients with stage-I or -II femoral head osteonecrosis according to the system by Ficat and Arlet. BMMCs were harvested and re-infused into the necrotic zone. The primary endpoints studied were safety, clinical symptoms and disease progression, these being assessed according to the Harris hip score (HHS) and to X-ray studies. RESULTS: After eight months, seven of the eight patients reported improvement from symptoms. There were no complications during anesthetic and surgery procedures. There was a significant postoperative increase in the HHS (98.3 +/- 2.5 points) compared to preoperative HHS (78.5 +/- 6.2 points) (p< 0.001). X-ray evaluation and cell parameters were found to be favorable. Conclusion: The autologous bone-marrow mononuclear cells implantation seems to be a safe and effective treatment for early stages of femoral head osteonecrosis in patients with sickle cell disease. Although promising, the interpretation of these early results is limited due to the small sample and to the short duration of follow-up. Further studies and advanced cellular assays are required to confirm the results.
Palavras-chave: Osteonecrosis
Sickle Cell Disease
Autologous transplantation
Bone marrow cells
Stem Cells
Editora / Evento / Instituição: Sociedade Brasileira de Ortopedia e Traumatologia
URI: http://www.repositorio.ufba.br/ri/handle/ri/6567
Data do documento: 2008
Aparece nas coleções:Artigo Publicado em Periódico (Faculdade de Medicina)

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