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metadata.dc.type: | Artigo de Periódico |
Title: | High serum nitric oxide levels in patients with severe leptospirosis |
Other Titles: | Acta Tropica |
Authors: | Maciel, Elves A. P. Athanazio, Daniel Abensur Reis, Eliana A. G. Cunha, Fernando Q. Queiroz, Adriano Almeida, Deusdélia Teixeira de Mcbride, Alan J. A. Ko, Albert I. Reis, Mitermayer Galvão dos |
metadata.dc.creator: | Maciel, Elves A. P. Athanazio, Daniel Abensur Reis, Eliana A. G. Cunha, Fernando Q. Queiroz, Adriano Almeida, Deusdélia Teixeira de Mcbride, Alan J. A. Ko, Albert I. Reis, Mitermayer Galvão dos |
Abstract: | Leptospirosis is a globally distributed zoonosis of major public health importance and is associated with severe disease manifestations such as acute renal failure and pulmonary haemorrhage syndrome. However, the extent to which the pathogenesis of leptospirosis mimics sepsis caused by Gram-negative bacteria remains unknown. The aim of this study was to evaluate serum levels of nitric oxide (NO) in patients diagnosed with severe leptospirosis. Sera from 35 confirmed cases of severe leptospirosis and 13 healthy subjects were analysed. Patients with severe leptospirosis had significantly higher NO levels compared to healthy individuals (30.82 ± 10.90 μM versus 3.86 ± 1.34 μM, P < 0.001), indicating that this immune mediator plays a role in the underlying systemic inflammatory response. |
Keywords: | Leptospirosis Nitric oxide Acute renal failure Pulmonary haemorrhage |
Publisher: | Acta Tropica |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/6307 |
Issue Date: | 2006 |
Appears in Collections: | Artigo Publicado em Periódico Estrangeiro (ISC) |
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