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https://repositorio.ufba.br/handle/ri/6276
metadata.dc.type: | Artigo de Periódico |
Title: | Reduction in diastolic blood pressure and cardiovascular mortality in nondiabetic hypertensive patients. a reanalysis of the HOT sudy |
Other Titles: | Arq. Bras. Cardiol. |
Authors: | Lopes, Antonio Alberto da Silva Andrade, Jadelson Noblat, Antonio Carlos Beisl Silveira, Marco Antonio |
metadata.dc.creator: | Lopes, Antonio Alberto da Silva Andrade, Jadelson Noblat, Antonio Carlos Beisl Silveira, Marco Antonio |
Abstract: | Objective - To use published Hypertension Optimal Treatment (HOT) Study data to evaluate changes in cardiovascular mortality in nondiabetic hypertensive patients according to the degree of reduction in their diastolic blood pressure. Methods - In the HOT Study, 18,700 patients from various centers were allocated at random to groups having different objectives of for diastolic blood pressure: ≤90 (n=6264); ≤85 n=6264); ≤80mmHg (n=6262). Felodipine was the basic drug used. Other antihypertensive drugs were administered in a sequential manner, aiming at the objectives of diastolic blood pressure reduction. Results - The group of nondiabetic hypertensive subjects with diastolic pressure ≤80mmHg had a cardiovascular mortality ratio of 4.1/1000 patients/year, 35.5% higher than the group with diastolic pressure ≤90mmHg (cardiovascular mortality ratio, 3.1/1000 patients/year). In contrast, diabetic patients allocated to the diastolic pressure objective group of ≤80mmHg had a 66.7% reduction in cardiovascular mortality (3.7/1000 patients/year) when compared with the diastolic pressure group of ≤90mmHg (cardiovascular mortality ratio, 11.1/1000 patients/year). Conclusion - The results indicate that in hypertensive diabetic patients reduction in diastolic blood pressure to levels ≤80mmHg decreases the risk of fatal cardiovascular events. It remains necessary to define the level of diastolic blood pressure ≤90mmHg at which maximal reduction in cardiovascular mortality is obtained for nondiabetics. |
Keywords: | Arterial hypertension HOT Study Diabetes mellitus |
Publisher: | Arquivos Brasileiros de Cardiologia |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/6276 |
Issue Date: | Aug-2001 |
Appears in Collections: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Files in This Item:
File | Description | Size | Format | |
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Lopes, Antonio Alberto.pdf | 27,07 kB | Adobe PDF | View/Open |
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