Please use this identifier to cite or link to this item:
https://repositorio.ufba.br/handle/ri/6194
metadata.dc.type: | Artigo de Periódico |
Title: | Granulocyte colony-stimulating factor treatment in chronic Chagas disease: preservation and improvement of cardiac structure and function |
Other Titles: | Faseb Journal |
Authors: | Macambira, Simone Garcia Vasconcelos, Juliana Fraga Costa, Claudio R. S. Klein, Wilfried Lima, Ricardo S. Guimarães, Patrícia Vidal, Daniel T. A. Mendez, Lucas C. Santos, Ricardo Ribeiro dos Soares, Milena Botelho Pereira |
metadata.dc.creator: | Macambira, Simone Garcia Vasconcelos, Juliana Fraga Costa, Claudio R. S. Klein, Wilfried Lima, Ricardo S. Guimarães, Patrícia Vidal, Daniel T. A. Mendez, Lucas C. Santos, Ricardo Ribeiro dos Soares, Milena Botelho Pereira |
Abstract: | This study investigates the effects of granulocyte colony-stimulating factor (G-CSF) therapy in experimental chronic chagasic cardiomyopathy. Chagas disease is one of the leading causes of heart failure in Latin America and remains without an effective treatment other than cardiac transplantation. C57BL/6 mice were infected with 103 trypomastigotes of Trypanosoma cruzi, and chronic chagasic mice were treated with G-CSF or saline (control). Evaluations following treatment were functional, immunological, and histopathological. Comparing hearts of G-CSFtreated mice showed reduced inflammation and fibrosis compared to saline-treated chagasic mice. G-CSF treatment did not alter the parasite load but caused an increase in the number of apoptotic inflammatory cells in the heart. Cardiac conductance disturbances in all infected animals improved or remained stable due to the G-CSF treatment, whereas all of the saline-treated mice deteriorated. The distance run on a treadmill and the exercise time were significantly greater in G-CSFtreated mice when compared to chagasic controls, as well as oxygen consumption (V˙ O2), carbon dioxide production (V˙ CO2), and respiratory exchange ration (RER) during exercise. Administration of G-CSF in experimental cardiac ischemia had beneficial effects on cardiac structure, which were well correlated with improvements in cardiac function and whole animal performance.— Macambira, S. G., Vasconcelos, J. F., Costa, C. R. S., Klein, W., Lima, R. S., Guimara˜es, P., Vidal, D. T. A., Mendez, L. C., Ribeiro-dos-Santos, R., Soares, M. B. P. Granulocyte colony-stimulating factor treatment in chronic Chagas disease: preservation and improvement of cardiac structure and function. |
Keywords: | chagasic cardiomyopathy inflammation arrhythmias treadmill performance |
Publisher: | Federation of American Society of Experimental Biology |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/6194 |
Issue Date: | Nov-2009 |
Appears in Collections: | Artigo Publicado em Periódico (EMV) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
(81)3843.full.pdf Restricted Access | 1,29 MB | Adobe PDF | View/Open Request a copy |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.