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metadata.dc.type: | Artigo de Periódico |
Title: | Influence of the HLA-DQB1*0201 allele on the immune response in a Schistosoma mansoni infection |
Other Titles: | ACTA Tropica |
Authors: | Reis, Eliana A. G. Athanazio, Daniel Abensur McBride, Alan J. A. Azevedo, Theomira Mauadi Carmo Santos, Isis F. Magalhães Harn, Donald Reis, Mitermayer Galvão dos |
metadata.dc.creator: | Reis, Eliana A. G. Athanazio, Daniel Abensur McBride, Alan J. A. Azevedo, Theomira Mauadi Carmo Santos, Isis F. Magalhães Harn, Donald Reis, Mitermayer Galvão dos |
Abstract: | We previously reported the association of the major histocompatibility complex class II HLA-DQB1*0201 allele with hepatosplenic schistosomiasis. The aim of this studywas to evaluate the cytokine responses of peripheral blood mononuclear cells (PBMCs) and the serum levels of immunoglobulin isotypes. The study population was selected from a schistosomiasis endemic area. No significant differences in cytokine profileswere detected in PBMCs stimulated with Schistosoma mansoni soluble egg antigen (SEA), regardless of the subjects DQB1*0201 genotype or infection status. However, previously infected DQB1*0201 positive individuals had significantly lower levels of IgG4 compared to DQB1*0201 negative individuals (P < 0.05). |
Keywords: | HLA Schistosomiasis Schistosoma mansoni Immunoglobulin isotype |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/6001 |
Issue Date: | 2008 |
Appears in Collections: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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