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metadata.dc.type: | Artigo de Periódico |
Title: | Neonatal exposure to citalopram, a serotonin selective reuptake inhibitor, programs a delay in the reflex ontogeny in rats |
Other Titles: | Arq Neuropsiquiatr |
Authors: | Deiró, Tereza Cristina Bomfim de Jesus Carvalho, Judelita Nascimento, Elizabeth do Medeiros, Jaiza Maria Barreto Cajuhi, Fabiana Pereira, Kelli Nogueira Ferraz Castro, Raul Manhães de |
metadata.dc.creator: | Deiró, Tereza Cristina Bomfim de Jesus Carvalho, Judelita Nascimento, Elizabeth do Medeiros, Jaiza Maria Barreto Cajuhi, Fabiana Pereira, Kelli Nogueira Ferraz Castro, Raul Manhães de |
Abstract: | Serotonin influences the growth and development of the nervous system, as well as its behavioral manifestations. The possibility exists that increased brain serotonin availability in young animals modulates their neuro-behavioral responses. This study investigated the body weight gain and reflex ontogeny of neonatal rats treated during the suckling period with two doses of citalopram (5 mg, or 10 mg/kg, sc, daily). The time of the appearance of reflexes (palm grasp righting, free-fall righting, vibrissa placing, auditory startle response, negative geotaxis and cliff avoidance) as well as the body weight evolution were recorded. In general, a delay in the time of reflex development and a reduced weight gain were observed in drug-treated animals. These findings suggest that serotoninergic mechanisms play a role in modulating body weight gain and the maturation of most reflex responses during the perinatal period in rats. |
Keywords: | Serotonin Programming SSRI Citalopram Reflex development |
Publisher: | Associação Arquivos de Neuro-Psiquiatria Dr. Oswaldo Lange |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/5852 |
Issue Date: | 2008 |
Appears in Collections: | Artigo Publicado em Periódico (Escola de Nutrição) |
Files in This Item:
File | Description | Size | Format | |
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Deiró, Teresa Cristina Bomfim de Jesus.pdf | 244,08 kB | Adobe PDF | View/Open |
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