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metadata.dc.type: | Artigo de Periódico |
Title: | Solid–Liquid Equilibrium of Substrates and Products of the Enzymatic Synthesis of Ampicillin |
Other Titles: | Aiche Journal |
Authors: | Santana, Mônica Leila Portela de Ribeiro, Marcelo P. A. Leite, Geisa A. Giordano, Raquel L. C. Giordano, Roberto C. Silva, Silvana Mattedi e |
metadata.dc.creator: | Santana, Mônica Leila Portela de Ribeiro, Marcelo P. A. Leite, Geisa A. Giordano, Raquel L. C. Giordano, Roberto C. Silva, Silvana Mattedi e |
Abstract: | The solid–liquid equilibrium of precursors and products of the enzymatic synthesis of ampicillin (AMP) [6-aminopencillanic acid (6-APA) and D( )phenylglycine (PG)] was investigated at different temperatures (283–298 K) and pHs (5.5–7.5). Solubility data were obtained using an analytical methodology. Equilibrium dissociation constants were experimentally measured at several temperatures for AMP, 6-APA, PG, and D( )phenylglycine methyl ester. A model based on the simplified perturbed hard sphere theory proposed by Khoshkbarchi and Vera (Ind Eng Chem Res. 1996;35:4319- 4327) was fitted against solubility data. The model could describe the water solubility behavior for AMP and PG as function of pH and temperature, but a bias was observed when fitting the model to the solubility of 6-APA. VVC 2009 American Institute of Chemical Engineers AIChE J, 56: 1578–1583, 2010 |
Keywords: | B-lactam antibiotics Green chemistry Solubility Solid–liquid equilibrium Thermodynamic modeling |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/5775 |
Issue Date: | 2010 |
Appears in Collections: | Artigo Publicado em Periódico (Química) |
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