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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/5768
Tipo: Artigo de Periódico
Título: Seropositivity to anti-phenolic glycolipid-I in leprosy cases, contacts and no known contacts of leprosy in an endemic and a non-endemic area in northeast Brazil
Título(s) alternativo(s): Transactions of the Royal Society of Tropical Medicine and Hygiene
Autor(es): Frota, Cristiane C.
Freitas, Max V. C.
Foss, Norma T.
Lima, Luana Nepomuceno Costa
Rodrigues, Laura C.
Barreto, Mauricio Lima
Kerr, Ligia Regina Franco Sansigolo
Autor(es): Frota, Cristiane C.
Freitas, Max V. C.
Foss, Norma T.
Lima, Luana Nepomuceno Costa
Rodrigues, Laura C.
Barreto, Mauricio Lima
Kerr, Ligia Regina Franco Sansigolo
Abstract: The seroprevalence rates of IgM anti-phenolic glycolipid-I (PGL-I) antibodies in four study groups with differing exposure to Mycobacterium leprae in Ceará, Brazil were investigated between March 2005 and August 2006. The first three groups in a high prevalence area included 144 cases of leprosy, their 380 contacts and 317 participants with no known leprosy contact. The fourth group in a low prevalence area consisted of 87 participants with no known leprosy contact living in an area in which no cases of leprosy had been reported in the previous 6 months. Seropositivity and levels of IgM antibodies to PGL-I were investigated using ELISA. The seropositivity levels of anti-PGL-I among the different clinical forms of leprosy cases were 61% for lepromatous, 25% for tuberculoid and 27% indeterminate. The levels of anti-PGL-I antibodies in the endemic area differentiated leprosy cases from noncases. However, the seropositivity was similar among contact cases (15.8%) and no known leprosy contact cases from high (15.1%) and low (13.8%) prevalence areas. The seropositivity of both contacts and no known contacts was much higher than previously reported among no known contacts in other endemic areas. The study indicates that anti-PGL-I antibodies are not useful as immunological markers of household leprosy contacts and no known leprosy contacts in endemic areas.
Palavras-chave: Leprosy
Mycobacterium leprae
Seroprevalence
Immunologic marker
Phenolic glycolipid-I
Brazil
URI: http://www.repositorio.ufba.br/ri/handle/ri/5768
Data do documento: 2010
Aparece nas coleções:Artigo Publicado em Periódico (Faculdade de Medicina)

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