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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/5675
Tipo: Artigo de Periódico
Título: Immunohistochemical detection of Ki-67 is not associated with tumor-infiltrating macrophages and cyclooxygenase-2 in oral squamous cell carcinoma
Título(s) alternativo(s): Journal of Oral Pathology & Medicine
Autor(es): Vilas Bôas, Deise Souza
Takiya, Christina Maeda
Coelho-Sampaio, Tatiana Lobo
Monção-Ribeiro, Leonardo Campos
Ramos, Eduardo Antônio Gonçalves
Cabral, Márcia Grillo
Santos, Jean Nunes dos
Autor(es): Vilas Bôas, Deise Souza
Takiya, Christina Maeda
Coelho-Sampaio, Tatiana Lobo
Monção-Ribeiro, Leonardo Campos
Ramos, Eduardo Antônio Gonçalves
Cabral, Márcia Grillo
Santos, Jean Nunes dos
Abstract: An inflammatory component consisting of cells and chemical mediators may influence the proliferation and dissemination of the oral squamous cell carcinoma (OSCC). In the present study, we evaluated the possible relationship between Ki-67, tumor-associate macrophages (TAMs), and COX-2 in OSCCs. In addition, the immunodetection of these proteins was associated with different histological grades of malignancy, including invasive and in situ tumors. METHODS: Twenty-seven OSCC cases were examined by light microscopy using criteria adopted WHO, and immunohistochemistry for Ki-67, CD68, and COX-2 using EnVision System in invasive and in situ lesions. Immunohistochemical detection of these proteins was assessed and scored for COX-2, and results were compared with their histological grades of malignancy. RESULTS: A correlation between Ki-67, COX-2, and CD68 was not found. Histological grade of malignancy (HDM) was associated with the Ki-67 immunostaining(P = 0.00), but this was not observed regarding both CD68 (P = 0.51) and COX-2 (P = 0.89). Furthermore, there was a COX-2 overexpression in 62.96% of the sample, and a high density of TAMs in both OSCCs and in situ carcinomas. CONCLUSIONS: Imunolabeling for Ki-67 was directly correlated with less-differentiated tumors, suggesting that this marker may contribute to understand the biological behavior of OSCC, and help to distinguish risk groups of OSCC. Furthermore, the lack of correlation between Ki-67, COX-2, and CD68 indicates that the latter two markers may play a pivotal role in oral carcinogenesis. However, further studies are needed to clarify their contribution for cell proliferation and tumor differentiation
Palavras-chave: cyclooxygenase-2
immunohistochemistry
Ki-67
Macrophages
squamous cell carcinoma
URI: http://www.repositorio.ufba.br/ri/handle/ri/5675
Data do documento: 2010
Aparece nas coleções:Artigo Publicado em Periódico (Faculdade de Odontologia)

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