Skip navigation
Universidade Federal da Bahia |
Repositório Institucional da UFBA
Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/5675
Registro completo de metadados
Campo DCValorIdioma
dc.contributor.authorVilas Bôas, Deise Souza-
dc.contributor.authorTakiya, Christina Maeda-
dc.contributor.authorCoelho-Sampaio, Tatiana Lobo-
dc.contributor.authorMonção-Ribeiro, Leonardo Campos-
dc.contributor.authorRamos, Eduardo Antônio Gonçalves-
dc.contributor.authorCabral, Márcia Grillo-
dc.contributor.authorSantos, Jean Nunes dos-
dc.creatorVilas Bôas, Deise Souza-
dc.creatorTakiya, Christina Maeda-
dc.creatorCoelho-Sampaio, Tatiana Lobo-
dc.creatorMonção-Ribeiro, Leonardo Campos-
dc.creatorRamos, Eduardo Antônio Gonçalves-
dc.creatorCabral, Márcia Grillo-
dc.creatorSantos, Jean Nunes dos-
dc.date.accessioned2012-04-19T18:53:22Z-
dc.date.issued2010-
dc.identifier.issn0904-2512-
dc.identifier.urihttp://www.repositorio.ufba.br/ri/handle/ri/5675-
dc.descriptionAcesso restrito: Texto completo. p. 565-570.pt_BR
dc.description.abstractAn inflammatory component consisting of cells and chemical mediators may influence the proliferation and dissemination of the oral squamous cell carcinoma (OSCC). In the present study, we evaluated the possible relationship between Ki-67, tumor-associate macrophages (TAMs), and COX-2 in OSCCs. In addition, the immunodetection of these proteins was associated with different histological grades of malignancy, including invasive and in situ tumors. METHODS: Twenty-seven OSCC cases were examined by light microscopy using criteria adopted WHO, and immunohistochemistry for Ki-67, CD68, and COX-2 using EnVision System in invasive and in situ lesions. Immunohistochemical detection of these proteins was assessed and scored for COX-2, and results were compared with their histological grades of malignancy. RESULTS: A correlation between Ki-67, COX-2, and CD68 was not found. Histological grade of malignancy (HDM) was associated with the Ki-67 immunostaining(P = 0.00), but this was not observed regarding both CD68 (P = 0.51) and COX-2 (P = 0.89). Furthermore, there was a COX-2 overexpression in 62.96% of the sample, and a high density of TAMs in both OSCCs and in situ carcinomas. CONCLUSIONS: Imunolabeling for Ki-67 was directly correlated with less-differentiated tumors, suggesting that this marker may contribute to understand the biological behavior of OSCC, and help to distinguish risk groups of OSCC. Furthermore, the lack of correlation between Ki-67, COX-2, and CD68 indicates that the latter two markers may play a pivotal role in oral carcinogenesis. However, further studies are needed to clarify their contribution for cell proliferation and tumor differentiationpt_BR
dc.language.isoenpt_BR
dc.sourceDOI: 10.1111/j.1600-0714.2010.00883.xpt_BR
dc.subjectcyclooxygenase-2pt_BR
dc.subjectimmunohistochemistrypt_BR
dc.subjectKi-67pt_BR
dc.subjectMacrophagespt_BR
dc.subjectsquamous cell carcinomapt_BR
dc.titleImmunohistochemical detection of Ki-67 is not associated with tumor-infiltrating macrophages and cyclooxygenase-2 in oral squamous cell carcinomapt_BR
dc.title.alternativeJournal of Oral Pathology & Medicinept_BR
dc.typeArtigo de Periódicopt_BR
dc.identifier.numberv. 39, n. 7pt_BR
dc.embargo.liftdate10000-01-01-
Aparece nas coleções:Artigo Publicado em Periódico (Faculdade de Odontologia)

Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
__onlinelibrary.wiley.co...6ba7216fccdef98ac0aa34d8faa27.pdf
  Restricted Access
273,72 kBAdobe PDFVisualizar/Abrir Solicitar uma cópia
Mostrar registro simples do item Visualizar estatísticas


Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.