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metadata.dc.type: | Artigo de Periódico |
Title: | NO donors-relaxation is impaired in aorta from hypertensive rats due to a reduced involvement of K+ channels and sarcoplasmic reticulum Ca2+-ATPase |
Other Titles: | Life Sciences |
Authors: | Bonaventura, Daniella Lima, Renata Galvão de Silva, Roberto Santana da Bendhack, Lusiane Maria |
metadata.dc.creator: | Bonaventura, Daniella Lima, Renata Galvão de Silva, Roberto Santana da Bendhack, Lusiane Maria |
Abstract: | Aims: To examine the vasodilatation induce by the NO donors, [Ru(terpy)(bdq)NO]3+ (TERPY) and sodium nitroprusside (SNP), and to compare their effects in aortic rings from hypertensive 2K-1C and normotensive 2K rats. Main methods: Vascular reactivity was performed in aortic rings pre-contracted with phenylephrine (Phe 100 nM). We have analyzed the maximal relaxation (Emax) and potency (pD2) of NO donors. Key findings: Potency of SNP was greater than TERPY in both arterial groups. The vasodilatation induced by TERPY was greater in 2K than in 2K-1C, and itwas inhibited by sGC inhibitor ODQ in 2K and in 2K-1C aortic rings. ODQ did not alter the efficacy to SNP, but it reduced its potency in 2K and 2K-1C. The blockade of K+ channels reduced the potency of TERPY only in aortic rings of 2K. On the other hand, the potency of SNP was reduced in both 2K and 2K-1C. The combination of ODQ and TEA reduced the relaxation induced by TERPY and SNP in 2K and reduced the efficacy to SNP in 2K-1C aortic rings but it had no additional effect on the TERPY relaxation in 2K-1C aortas. The production of cGMP induced by TERPY was greater than that produced by SNP, which was similarly increased in 2K and 2K-1C. Sarcoplasmic reticulum Ca-ATPase inhibition only impaired the relaxation induced by SNP in 2K aortic rings. Significance: Taken together, our results provide evidences that in this model of hypertension, impaired K+ channels activation by TERPY and SERCA activation by SNP may contribute to decreased vasodilatation. |
Keywords: | Nitric oxide donor Renal hypertension K+ channel |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/5370 |
Issue Date: | 2011 |
Appears in Collections: | Artigo Publicado em Periódico (Química) |
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