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https://repositorio.ufba.br/handle/ri/5268
metadata.dc.type: | Artigo de Periódico |
Título : | Coinfection by HTLV-I/II is associated with an increased risk of strongyloidiasis and delay in starting antiretroviral therapy for AIDS patients |
Otros títulos : | The Brazilian Journal of Infectious Diseases |
Autor : | Brites, Carlos Martins Netto, Eduardo Jorge, Célia Regina Mayoral Pedroso Sampaio, Diana Brasil Pedral Harrington Júnior, W. Goyanna, F. Adriano, S. |
metadata.dc.creator: | Brites, Carlos Martins Netto, Eduardo Jorge, Célia Regina Mayoral Pedroso Sampaio, Diana Brasil Pedral Harrington Júnior, W. Goyanna, F. Adriano, S. |
Resumen : | Objective: To compare the clinical characteristics and outcomes of HIV-1-HTLV-1 coinfected patients, in Bahia, Brazil. Methods: Retrospective, comparative study. Results: Among a total of 123 consecutive HIV infected patients, 20 men (20.6%) and 6 women (23.1%) had detectable antibodies against HTLV-I/II. The major risk factor associated with coinfection by HTLV was intravenous drug use (57.7% of coinfected patient versus 9.2% of HTLV seronegative patients, p < 0.0001). Coinfected patients had higher absolute lymphocyte counts (1,921 + 762 versus 1,587 + 951, p = 0.03). Both groups of patients had similar means of CD4+ and CD8+ cell counts. However, among patients with AIDS CD4+ cell counts were signifi cantly higher among those coinfected with HTLV-I/II (292 ± 92 cells/mm3, versus 140 ± 177cells/mm3, p = 0.36). The frequency and type of opportunistic infections were similar for both groups, but strongyloidiasis and encephalopathy were more frequently diagnosed in coinfected patients (p < 0.05). On the other hand, patients coinfected with HTLV-I/II received signifi cantly less antiretroviral therapy than singly infected by HIV-1. Conclusion: Coinfection by HTLV-I/II is associated with an increased risk of strongyloidiasis for HIV patients. Higher CD4 count may lead to underestimation of immunodefi ciency, and delay to initiate antiretroviral therapy. |
Palabras clave : | HIV HTLV-I/II coinfection Strongyloidiasis CD4/CD8 |
URI : | http://www.repositorio.ufba.br/ri/handle/ri/5268 |
Fecha de publicación : | 2011 |
Aparece en las colecciones: | Artigo Publicado em Periódico Estrangeiro (ISC) |
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Fichero | Descripción | Tamaño | Formato | |
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v15n1a02.pdf | 285,18 kB | Adobe PDF | Visualizar/Abrir |
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