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metadata.dc.type: | Artigo de Periódico |
Title: | Incidence of psychiatric side e¡ects during pegylated interferon- a retreatment in nonresponder hepatitisCvirus-infected patients |
Other Titles: | Liver International |
Authors: | Quarantini, Lucas de Castro Bressan, Rodrigo Affonseca Galvão, Amanda Neves, Susana Carolina Batista Paraná, Raymundo |
metadata.dc.creator: | Quarantini, Lucas de Castro Bressan, Rodrigo Affonseca Galvão, Amanda Neves, Susana Carolina Batista Paraná, Raymundo |
Abstract: | Objective: Evaluate the incidence of mental disorders using pegylated interferon plus ribavirin retreatment in nonresponder hepatitis C virus-infected patients. Method: The Mini-International Neuropsychiatric Interview (MINI) was used to evaluate 30 hepatitis C virus-infected interferon-nonresponder patients at baseline and following 4, 12 and 24 weeks of pegylated interferon retreatment. Results: During the pegylated interferon/ribavirin retreatment, 5(16.6%) patients developed psychiatric side effects: 3(10%) were diagnosed with major depressive disorder, 1(3.3%) had a brief psychotic disorder and 1(3.3%) presented with panic attacks. Conclusion: This is the first prospective study evaluating the incidence of neuropsychiatric side effects during interferon retreatment of hepatitis C virusinfected patients, suggesting that the risk of acquiring serious psychiatric symptoms during retreatment with interferon-a (IFN-a) may not be higher than during the first antiviral therapy. This finding challenges the hypothesis that during a second treatment with IFN-a, patients with hepatitis C may be at greater risk for neuropsychiatric side effects than naïve patients. |
Keywords: | comorbidity hepatitis C interferon psychiatric side effects retreatment |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/5253 |
Issue Date: | 2007 |
Appears in Collections: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Files in This Item:
File | Description | Size | Format | |
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j.1478-3231.2007.01532.x.pdf | 76,76 kB | Adobe PDF | View/Open |
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