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https://repositorio.ufba.br/handle/ri/4994
metadata.dc.type: | Artigo de Periódico |
Title: | Multiple opioid receptors mediate the hypotensive response induced by central 5-HT3 receptor stimulation |
Other Titles: | Neuropeptides |
Authors: | Fregoneze, Josmara Bartolomei Oliveira, Elenilda Farias Ribeiro, Vanessa Fonseca Ferreira, Hilda Silva Silva, Emilio Jose de Castro e |
metadata.dc.creator: | Fregoneze, Josmara Bartolomei Oliveira, Elenilda Farias Ribeiro, Vanessa Fonseca Ferreira, Hilda Silva Silva, Emilio Jose de Castro e |
Abstract: | The aim of the present work was to investigate the role of brain l, j and d opioid receptors in the central serotonergic mechanisms regulating blood pressure in rats. The data obtained show that: (1) pharmacological activation of central 5-HT3 receptors yields a significant decrease in blood pressure; (2) the blockade of those receptors by a selective antagonist induces an acute hypertensive response; (3) the pharmacological blockade of central opioid receptors by three different opioid antagonists exhibiting variable degrees of selectivity to l, j and d opioid receptors always suppressed the hypotensive response induced by central 5-HT3 receptor stimulation; (4) the blockade of opioid receptors by the same opioid antagonists that impaired the hypotensive effect of central 5-HT3 receptor stimulation failed to modify blood pressure in animals not submitted to pharmacological manipulations of central 5-HT3 receptor function. It is shown that a 5-HT3 receptor-dependent mechanism seems to be part of the brain serotonergic system that contributes to cardiovascular regulation since the hypertensive response observed after ondansetron administration indicates that central 5-HT3 receptors exert a tonic inhibitory drive on blood pressure. Furthermore, the data obtained here clearly indicate that the hypotensive response observed after pharmacological stimulation of central 5-HT3 receptors depends on the functional integrity of brain l, j and d opioid receptors, suggesting that a functional interaction between serotonergic and opiatergic pathways in the brain is part of the complex, multifactorial system that regulates blood pressure in the central nervous system. |
Keywords: | 5-HT3 receptors Opioid receptors Blood pressure |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/4994 |
Issue Date: | 2011 |
Appears in Collections: | Artigo Publicado em Periódico (ICS) |
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