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metadata.dc.type: | Artigo de Periódico |
Title: | Cytokine Profile and Immunomodulation in Asymptomatic Human T-Lymphotropic Virus Type 1-Infected Blood Donors |
Other Titles: | Journal of acquired immune deficiency syndromes and human retrovirology |
Authors: | Carvalho Filho, Edgar Marcelino de Porto, Maria Aurélia da Fonseca Bacellar, Maria Olívia Amado Ramos Braga, Silvane Castro, Bernardo Galvão Neva, Franklin A. |
metadata.dc.creator: | Carvalho Filho, Edgar Marcelino de Porto, Maria Aurélia da Fonseca Bacellar, Maria Olívia Amado Ramos Braga, Silvane Castro, Bernardo Galvão Neva, Franklin A. |
Abstract: | The modulation of the immune response has been used as therapy for clinical disorders associated with human T-lymphotropic virus type 1 (HTLV-1) infection. In this study, the cytokine profile was evaluated in 26 asymptomatic HTLV-1 blood donors. Additionally, both the cell responsible for producing interferon-γ (IFN-γ) and the role of exogenous interleukin (IL)-10 in downregulating IFN-γ production were studied. Cytokine levels were determined in supernatants of unstimulated lymphocyte cultures by enzyme-linked immunosorbent assay. The levels of IFN-γ, tumor necrosis factor-α, IL-5, and IL-10 were higher in supernatants of the lymphocyte cultures taken from HTLV-1-infected donors than in those taken from healthy subjects. Although depletion of CD8+ T cells and natural killer cells did not affect IFN-γ production, depletion of CD4+ T cells significantly decreased IFN-γ production. Furthermore, at a concentration of 2 ng/ml, IL-10 had only a minimum effect on IFN-γ producti on, although at high concentrations (100 ng/ml), IL-10 decreased IFN-γ production by 50% in HTLV-1-infected individuals. These data indicate that both T helper 1 and T helper 2 cytokines are elevated in HTLV-1 infection and that IL-10 in high concentrations modulates IFN-γ production in these patients. |
Keywords: | Cellular immunity in HTLV-1 Cytokines in HTLV-1 HTLV-1 Immune response in HTLV-1 Immunomodulation in HTLV-1 |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/4834 |
Issue Date: | 2001 |
Appears in Collections: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Files in This Item:
File | Description | Size | Format | |
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Cytokine Profile.pdf | 135,16 kB | Adobe PDF | View/Open |
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