Pericárdio bovino descelularizado no tratamento de queimadura

Abstract

Introduction - Treatment of the burned patient at the appropriate time prevents the occurrence of sequelae. The use of collagen-based skin substitutes can promote a sterile wound and serve as a framework for the healing process to occur. Objective - To evaluate tissue repair after the application of decellularized bovine pericardium biomaterial for the treatment of cutaneous burns. Methodology - This was an intervention study on experimental research with 48 rats, divided into two groups; with the experimental group being submitted to thermal burn on the back of the animals, by the brass plate method. After being burned, the experimental group received treatment with decellularized bovine pericardium biomaterial. The other group received treatment with rayon dressing soaked with petrolatum. The animals were sacrificed and evaluated histomorphologically at the biological time intervals of 7, 15, 28 and 60 postoperative days. Results - There was formation of granulation tissue with collagen fibers positioned in a more parallel manner and with less leukocyte fibrin exudate in the initial period of treatment in the experimental group. Maintenance of the biomaterial covering of the burned tissue was observed in up to 28 days. At the end of the 60 days, the control group presented a higher mean cicatricial contraction value when compared with that of the experimental group. Conclusion: The biomaterial was biocompatible, promoted the stability of the lesion and increased repair of the cutaneous lesion caused by the burn.