Avaliação das citocinas IL-2, IL-12, IFN-y e TNF-a como preditores de mortalidade em pacientes com COVID-19 en estadi grave admitidos à unidade de terapia intensiva

Abstract

COVID-19, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2), has caused numerous clinical manifestations that can lead to death. In a short period of time, the disease spread globally, mainly affecting individuals with comorbidities such as hypertension and diabetes. Studies demonstrate the participation of the individual's immune system in the patient's clinical evolution as well as its outcome and, therefore, the study addresses the role of certain cytokines in regulating the immune response and the comparison between them. This is a cross-sectional study, approved by the National Research Ethics Commission (CONEP) and aimed to evaluate the serum levels of Th1 response cytokines (IL-2, IL-12, INF-y and TNF-a) hospitalized. in serious condition in an intensive care unit at the Hospital Geral of Vitória da Conquista in state of Bahia. The study was carried out on 56 patients with an average of 64 years old, ranging between 16 and 97 years old, with the majority of patients being female (58.3) and, as a result, it was applied that plasma concentrations of IL-2 and INF -y are present in patients affected by COVID-19 in serious condition.