Análise oxidativa, parametros clínicos laboratoriais e qualidade de vida no tratamento associado à ozonioterapia em cadelas com tumores de mama

Abstract

In view of the high frequency of involvement, morbidity and mortality in female dogs with mammary tumors, an integrative treatment was sought that could promote an improvement in the antioxidant response and quality of life of these animals. In this context, the objective was to evaluate the oxidative profile: through the total antioxidant capacity (TAC) and the concentration of malondialdehyde (MDA), the clinical and laboratory response (red blood cells, platelets, relative and absolute lymphocytes, urea, creatinine, alanine aminotransferase and alkaline phosphatase) and the quality of life score of patients before and after mastectomy. A total of 180 female dogs were evaluated. Of these, 49 were selected and divided into five groups, one group as a control healthy group (GH): healthy dogs, with no history of breast tumors; and four experimental groups: mastectomy Group (GM): dogs with breast tumor submitted only to mastectomy; GMO3: female dogs with breast tumor, submitted to mastectomy and ozone therapy (ozonated minor autohemotherapy) at the VG14 acupoint (dahzhui) in the pre and postoperative periods; GMAHT: dogs with breast tumor, submitted to mastectomy and autohemotherapy at acupoint VG14, in the pre and postoperative periods and GMA: dogs with breast tumor, submitted to mastectomy and acupuncture at acupoint VG14, in the same periods. The use of ozone therapy and the quality of life score were evaluated in comparison with the other experimental groups in five moments: initial clinical evaluation (D0); preoperative evaluation (D1); mastectomy (D2); evaluation of the surgical wound (D3) and removal of surgical stitches (D4). Three of the moments (D0, D2 and D4) were considered main, for the evaluation of the oxidative profile and two of them (D0 and D4), for the hematological parameters. There was a significant increase in the quality of life score, from D0 (26.4) to D2 (27.5) and to D4 (32). In the oxidative profile of GMO3, from D0 to D4, there was a progressive increase in the global mean TAC from 12.74 to 19.39 and a reduction in MDA from 446.1 to 150.5. In the hematological profile, related to renal function, there was a reduction in the global average of creatinine (p=0.009), in D0 from D4. The evaluation of the epidemiological clinical parameters showed a statistically significant association between ozone therapy and an increase in antioxidant capacity, a reduction in oxidative stress and an increase in the quality of life score. GMO3 performed better than the other experimental groups studied (GM, GMAHT and GMA). The evaluated results suggest that ozonized autohemotherapy, before and after mastectomy, represented a viable, economical and safe treatment possibility to optimize the antioxidant response, reduce oxidative damage and, consequently, provide a better quality of life for patients with breast cancer.