Infusão intravenosa de lidocaína em cadelas com piometra submetidas à ovariohisterectomia e anestesiadas com propofol L

Abstract

IWASSA, C. H. D. Salvador, 2022. Intravenous infusion of lidocaine in female dogs with pyometra undergoing ovariohysterectomy, anesthetized with propofol. 64p. Thesis (Master in Animal Science on Tropics) – School of Veterinary Medicine and Zootechny – Federal University of Bahia. Pyometra is a common disease in adult female dogs, caused by physiological hormonal changes associated with bacterial infection. The infectious-inflammatory condition can progress to sepsis and ovariohysterectomy (OH) is the standard treatment. Lidocaine is a local anesthetic that produces analgesic and anti-inflammatory actions by the intravenous route. The aim of this study was to evaluate the effects of continuous infusion of lidocaine in female dogs with pyometra undergoing to OH. Sixteen dogs participated of the study after being screened using the quick SOFA scale and meeting the inclusion criteria. Dexmedetomidine and tramadol were used for premedication and bitches were induced and kept under propofol anesthesia. After anesthetic induction, animals were randomly allocated into two groups (n = 8) designated: LG, treated with lidocaine (2 mg/kg; 100 g/kg/min.) and GC, which received 0.9% NaCl in identical volume and rates. The thesis results were presented in two chapters, outlined according to the variables evaluated. In the first chapter, the assessment of cardiorespiratory parameters and propofol requirement revealed, for the LG, a significantly lower mean infusion rate of propofol infusion compared to CG (p = 0.016), as well as no interference of lidocaine in the physiological variables studied, during the OH. In the second chapter, postoperative analgesic assessment using the University of Melbourne Pain Scale (UMPS) revealed an increase in analgesia in the first 90 minutes after surgery. The use of lidocaine did not interfere in the time and quality of the animals' recovery, discarding adverse effects. It is concluded that continuous infusion of lidocaine does not interfere with cardiorespiratory parameters and reduces the intraoperative requirement of propofol. In addition, it improves immediate postoperative analgesia (90 minutes) and does not interfere with the time and quality of the animals' recovery, proving to be safe for female dogs with pyometra undergoing OH.