Skip navigation
Universidade Federal da Bahia |
Repositório Institucional da UFBA
Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/40191
Registro completo de metadados
Campo DCValorIdioma
dc.creatorOrrico, Keith Fróes-
dc.date.accessioned2024-09-13T17:26:59Z-
dc.date.available2024-07-26-
dc.date.available2024-09-13T17:26:59Z-
dc.date.issued2019-02-18-
dc.identifier.citationORRICO, Keith Fróes. Frequência de disfunção sexual entre mulheres infectadas pelo Vírus Linfotrópico da célula T Humana Tipo 1. Dissertação (Mestrado) – Universidade Federal da Bahia, Faculdade de Medicina da Bahia, Programa de Pós-Graduação em Ciências da Saúde, 2019.pt_BR
dc.identifier.urihttps://repositorio.ufba.br/handle/ri/40191-
dc.description.abstractIntroduction: Human T-lymphotropic virus type 1 (HTLV-1) is the main agent of myelopathy associated with HTLV-1 or tropical paraparespatic (MAH / PET). Clinical and neurological manifestations in patients infected with HTLV-1 without myelopathy are documented at a higher frequency in HTLV-1 carriers than in seronegative controls, but little is known about the ability of this virus to cause female sexual dysfunction. These manifestations can negatively affect the sexual life of these women. Objectives: To assess the frequency and main manifestations of sexual dysfunction (DS) in HTLV-1 infected women, correlating them with pro-viral load and neurological impairment. Methods: Cross-sectional study carried out at the HPLES Multidisciplinary Outpatient Clinic of HTLV. Data collected by the Female Sexual Function Index (FSFI) questionnaire and the form containing socio-demographic and clinical variables. A total of 140 women between 20 and 55 years of age and with sexual interest were included, matched by age, 70 in each group. Results: There was no difference between the groups regarding age, self-reported color, type of delivery, marital status, age of coitare and menopause. It was found that 70% of the cases presented DS in relation to 25,7% of the control (p <0.001) and that the HTLV-1 group had 3,53 more chances to present DS. Women with HTLV-1 infection had less desire (p <0.001), arousal (p <0.001), lubrication (p <0.001), sexual satisfaction (p <0.001), orgasm (p <0.001) than the control. Sexual satisfaction was significantly lower in HTLV-1 carriers, and the correlation between neurological impairment and DS (R = 0.53, p <0.001) and between pro-viral load and DS (R = 0.32, p <0.001) was moderateand weak, respectively. Conclusion: DS is more common in women infected with HTLV-1 than in controls, and in addition to neurological involvement, other factors may play a role in DS associated with HTLV-1 infection.pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq; Fundação de Amparo à Pesquisa do Estado da Bahia Bolsa de Estudo -FAPESBpt_BR
dc.languageporpt_BR
dc.publisherUNIVERSIDADE FEDERAL DA BAHIApt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectVírus linfotrópico de células T humana 1pt_BR
dc.subjectDisfunção sexualpt_BR
dc.subjectÍndice de função sexual feminina (IFSF)pt_BR
dc.subject.otherHuman T-cell lymphotropic virus 1pt_BR
dc.subject.otherSexual dysfunction Femalept_BR
dc.subject.othersexual function index (FSFI)pt_BR
dc.titleFrequência de disfunção sexual entre mulheres infectadas pelo Vírus Linfotrópico da célula T Humana Tipo 1pt_BR
dc.typeDissertaçãopt_BR
dc.publisher.programPós-Graduação em Ciências da Saúde (POS_CIENCIAS_SAUDE) pt_BR
dc.publisher.initialsUFBApt_BR
dc.publisher.countryBrasilpt_BR
dc.subject.cnpqCNPQ::CIENCIAS DA SAUDEpt_BR
dc.contributor.advisor1Carvalho Filho, Edgar Marcelino de-
dc.contributor.referee1Carvalho, Edgar Marcelino-
dc.contributor.referee2Andrade, Rosana Cristina Pereira de-
dc.contributor.referee3Oliveira, Eduardo Martins Netto de-
dc.creator.IDhttps://orcid.org/0000-0001-7385-307Xpt_BR
dc.creator.Latteshttp://lattes.cnpq.br/8061615284388224pt_BR
dc.description.resumoIntrodução: O vírus T-linfotrópico humano tipo 1 (HTLV-1) é o principal agente da mielopatia associada ao HTLV-1 ou paraparesiaespástica tropical (MAH/PET). Manifestações clínicas e neurológicas em pacientes infectados com HTLV-1 sem mielopatia são documentadas em frequência mais elevada em portadores do HTLV-1 que em controles soronegativos, mas pouco se sabe da capacidade deste vírus em causar disfunções sexuais femininas. Essas manifestações podem afetar negativamente a vida sexual dessas mulheres. Objetivos: Avaliar a frequência e as principais manifestações de disfunção sexual (DS) em mulheres infectadas pelo HTLV-1, correlacionando-as com a carga pró-viral e comprometimento neurológico. Métodos: estudo de corte transversal realizado no Ambulatório Multidisciplinar de HTLV do HUPES. Dados coletados pelo questionário Female Sexual Function Index (FSFI) e formulário contendo variáveis sócio demográficas e clínicas. Foram incluídas 140 mulheres entre 20 a 55 anos e com interesse sexual, pareadas por idade, 70 em cada grupo. Resultados: Não houve diferença entre os grupos em relação à idade, cor auto referida, tipo de parto, estado civil, idade da coitarca e da menopausa. Constatou-se que 70% dos casos apresentavam DS em relação a 25,7% do controle (p<0,001) e que o grupo HTLV-1 possuía 3,53 mais chances de apresentar DS. As mulheres infectadas pelo HTLV-1 tinham menos desejo (p <0.001), excitação (p <0.001), lubrificação (p <0.001), satisfação sexual (p <0.001), orgasmo (p <0.001) e dor (p <0.001) do que o controle. A Satisfação sexual foi significativamente menor nas portadoras de HTLV-1, e a correlação entre comprometimento neurológico e DS (R = 0,53, p <0,01) e entre carga pró-viral e DS (R = 0,32, p <0,001) foi moderado e fraco, respectivamente. Conclusão: A DS é mais frequente nas mulheres infectadas com HTLV-1 do que nos controles, e, além do envolvimento neurológico, outros fatores podem desempenhar um papel na DS associado à infecção pelo HTLV-1.pt_BR
dc.publisher.departmentFaculdade de Medicina da Bahiapt_BR
dc.relation.referencesAbdo CH, Oliveira WM JR, Moreira Júnior ED, Fittipaldi JA. Prevalence of sexual dysfunctions and correlated conditions in a sample of Brazilian women: results of the Brazilian study on sexual behavior (BSSB). Int J Impot Res. 2004 Apr; 16 (2): 160-6. Adenilda Lima Lopes Martins, Maria Fernanda Rios Grassi, Alisson de Aquino Firmino, Jean Paulo Lacerda Araujo, Taiane Silva Paixao, Bernardo Galvão-Castro, Ney Boa-Sorte. Human T-Lymphotropic Virus-1 - Associated Myelopathy/Tropical Spastic Paraparesis Is Associated With Sexual Dysfunction in Infected Women of Reproductive AgeSexual Dysfunction in HAM/TSP Women. Sex Med. 2018;6:324- 331. American Psychiatric Association. Highlights of changes from the DSM-IV to DSM-5. Washington. DC: American Psychiatric Press; 2013. Andrade R, Tanajura D, Santana D, Santos D, Carvalho EM. Association between urinary symptoms and quality of life in HTLV-1 infected subjects without myelopathy. International Brazilian Journal of Urology, 39 (6): 861-66, 2013. Araujo AQC, Silva MTT, The HTLV-1 neurological complex. The Lancet Neurology, 5:1068-76, 2006. Araya N, Sato T, Ando H, Tomaru U, Yoshida M, Coler-Reilly A, Yagishita N, Yamauchi J, Hasegawa A, Kannagi M, Hasegawa Y, Takahashi K, Kunitomo Y, Tanaka Y, Nakajima T, Nishioka K, Utsunomiya A, Jacobson S, Yamano Y. HTLV-1 induces a Th1-like state in CD4+CCR4+ T cells. The Journal of Clinical Investigation, 124(8):3431- 42, 2014. Bangham CR. The immune response to HTLV-I. Curr Opin Immunol. 2000 Aug; 12(4):397–402. Barak Y, Achiron A, Elizur A, Gabbay U, Noy S, Sarova-Pinhas I. Sexual dysfunction in relapsing-remitting multiple sclerosis: magnetic resonance imaging, clinical, and psychological correlates. Journal of psychiatry &neuroscience: JPN. 1996;21(4):255-8. Basson, R. The female sexual response: a different model. J Sex Marital Ther. 2000; 26(1):51-65. Bernardo Galvão-Castro, Luiz C. Junior Alcântara, Maria Fernanda R. Grassi, Aline C.A. Mota-Miranda, Artur, T.L. de Queiroz, Filipe F.A. Rego, Augusto Cesar A. Mota, Sérgio A. Pereira, Temístocles Magalhães, José Tavares-Neto, Marilda Souza Gonçalves, Inês Dourado. HTLV-I epidemiologyandorigin in Salvador, stateof Bahia: thecitywiththehighestprevalenceofthisinfection in Brazil. Gaz. Méd. Bahia 2009; 79:1(Jan-Dez): 3-10. Brito-Melo GE, Souza JG, Barbosa-Stancioli EF, Carneiro-Proietti AB, Catalan-Soares B, Ribas JG. Establishing phenotypic features associated with morbidity in human T–cell lynphotropic virus type 1 infection. ClinDiagn Lab Immunol, 11 (6): 1105-1110, 2004. Bronner G, Elaran E, Golomb AD, Korczyn: Female sexuality in multiple sclerosis: the multi dimentional nature of the problem and the intervention. ActaNeurolScand 2010, 121:289–301. Burri A, Hysi P, Clop A, Rahman Q, Spector TD. A genome-wide association study of female sexual dysfunction. PLoS One. 2012; 7(4): e 35041. Carneiro-Proietti AB, Catalan-Soares BC, Murphy EL et al. Global epidemiology of HTLV-I infection and associated disease. Oncogene. 2005;24(39): 6058-68. Carneiro-Proietti ABF, et al. Infecção e doença pelos vírus linfotrópicos humanos de células T (HTLV-I/II) no Brasil. Rev. Soc. Bras. Med. Trop. Oct; 35(5): 499-508 2002. Carod-Artal FJ, Mourão MH, Ribeiro L.S. Neurological symptoms and disability in HTLV-1 associated myelopathy. Neurologia, 23: 78-84, 2008. Carvalho EM, Bacelar O, Porto AF, Braga S, Galvão-Castro B, Neva F. Cytokine profile and immunomodulation in asymptomatic human T-lymphotropic virus type 1-infected blood donors. Journal Acquired Immune Deficiency Syndromes Human Retrovirology, May 1; 27(1):1-6, 2001. Caskey MF, Morgan DJ, Porto AF, Giozza SP, Muniz AL, Orge GO, Travassos MJ, Barrón Y, Carvalho EM, Glesby MJ. Clinical manifestations associated with HTLV type I infection: A cross-sectional study. AIDS Res Hum Retroviruses. 2007, 23: 365- 71. Casseb J and Penalva-de-Oliveira A.C. The pathogenesis of tropical spastic paraparesis/human T-cell leukemia type I-associated myelopathy. Brazilian Journal of Medical and Biological Research, 33: 1395-1401, 2000. Cassar O. Epidemiological aspects and world distribution of HTLV-1 infection. Frontiers Microbiology, Nov 15; 3:388, 2012. Castro N, Oliveira P, Freitas D, Rodrigues W, Muniz A, Carvalho E. Erectile dysfunction and HTLV-I infection: a silent problem. Int J Impot Res 2005;17(4):364-369. Castro NM, Freitas DM, Rodrigues Junior W, Muniz A, Oliveira P, Carvalho EM. Urodynamic Features of the Voiding Dysfunction in HTLV-1 Infected Individuals. International Brazilian Journal of Urology, 33 (2): 238-45, 2007. Castro NM, Rodrigues W Jr, Muniz A, Luz GO, Porto AM, Machado A, Carvalho, EM Bexiga neurogênica como primeira manifestação de infecção pelo HTLV 1- Relato de Caso. DST – Jornal Brasileiro de Doenças Sexualmente Transmissíveis, 14 (5):32- 4, 2002. Catalan-Soares BC, Proietti FA, Carneiro-Proietti ABF. Os vírus linfotrópicos de células T humanos (HTLV) na última década (1990-2000) - Aspectos epidemiológicos. Revista Brasileira de Epidemiolgia, 4(2): 81-95, 2001. Coelho-dos-Reis JG, Rocha RD, Brito-Melo GE, Carneiro-Proietti AB, Catalan-Soares, Barbosa-Stancioli EF, Martins-Filho AO, Grupo Interdisciplinar de Pesquisas em HTLV. Avaliação do desempenho de parâmetros imunológicos como indicadores de progressão clínica da infecção crônica pelo HTLV-1. Revista da Sociedade Brasileira de Medicina Tropical, 40(1):29-36, 2007. Collumbien M, Busza J, Cleland J, Campbell O. Social sciencemethods for researchon sexual andreproductivehealth. Geneva: WHO; 2012. De Almeida DM, Benetti-Pinto CL, Makuch MY. Sexual function of women with premature ovarian failure. Menopause 2011; 18:262-266. ThielRdo R, Dambros M, Palma PCR, et al. Tradução para português, adaptação cultural e validação do Female Sexual Function Index. RevBrasGinecolObstet 2008;30:504-510. De Castro-Costa CM, Araújo AQC, Barreto MM, Takayanagui OM, Sohler MP, Silva EL, De Paula SMB, et al. Proposal for Diagnostic Criteria of Tropical Spastic paraparesis/HTLV-1 -Associated Myelopathy (TSP/HAM). AIDS Research and Human Retrovirus, 931-5, 2006. Demirkiran M, Sarica Y, Uguz S, Yerdelen D, Aslan K. Multiple sclerosis patients with and without sexual dysfunction: are there any differences? MultScler 2006; 12: 209–14. Dourado I, Alcântara LCJ, Barreto ML, Teixeira MG, Galvão-Castro B. HTLV- I in the general populationof Salvador, Brazil. Journal of Acquired Immune Deficiency Syndromes, 34(5):527-31, 2003. Franzoi AC, Araujo AQ. Disability and determinants of gait performance in tropical spastic paraparesis/HTLV-I associated myelopathy (HAM/TSP). The JournalofSpinal Cord Medicine, 45:64-68, 2006. Garlet GP, Giozza SP, Silveira EM, Claudino M, Santos SB, Avila-Campos MJ, Martins W Jr, Cardoso CR, Trombone AP, Campanelli AP, Carvalho EM, Silva JS. Association of human T linphotropic virus I aplification of periodontitis severity with altered cytokine expression in response to a standard periodontopathogen infection. Clin Infect Dis. 2010, 50: 11-18. Gascon, Maria Rita Polo et al. The impactofurinaryincontinenceonthequalityoflifeandonthesexualityofpatientswith HAM/TSP. Braz J InfectDis [online].2018, vol.22, n.4, pp.288-293. Gessain A, Mahieux R, de Thé G. Genetic variability and molecular epidemiology of human and simian T cell leukemia/lymphoma virus type I. Journal Acquired Immune Deficiency Syndromes Human Retrovirology, 13 Suppl 1:S132-45, 1996. Gotuzzo E, Moody J, Verdonck K, Cabada MM, González E, Dooren SV, et al. Frequent HTLV-1 infection in the offspring of Peruvian women with HTLV-associated myelopathy/tropical spastic paraparesis or strongyloidiasis. Rev PanamSaludPublica. 2007; 22:223-30. Grant C, Barmak K, Alefantis T, Yao J, Jacobson S, Wigdahl B. Human T-cell leukimia virus type I and neurologic disease: events in bone marrow, peripheral blood, and central nervous system during normal immune survellance and neuroinammation. Journal of Cellular Physiology. 190 (2): 133159, 2002. Graziottin A. Prevalence and evaluation of sexual health problems: HSDD in Europe. J Sex Med. 2007 Mar; 4 (3): 211-9. Hinuma Y, Nagata K, Hanaoka M, Nakai M, Matsumoto T, Kinoshita KI, Shirakawa S, Miyoshi I. Adult T cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera. Proceedings of the National Academy of Sciences of the United States of America, 78: 6476-80, 1981. I Gruenwald et al. Sexual dysfunction in females with multiple sclerosis: quantitative sensory testingMultiple Sclerosis 2007; 13: 95105. Borello-France D, Leng W, O’Leary M, Xavier M, Erickson J et al. Bladder and sexual function among women with multiple sclerosis. MultScler 2004; 10: 455–61. Junuzovic D, Mehmedbasic S. [Erectile dysfunction--incidence, causes and risk factors]. Med Arh 2004;58(1):35-38. Kajiyama W, Kashiwagi S, Hayashi J, Nomura H, Okochi K. Intrafamilial transmission of adult T cell leukemia virus. J Infect Dis. 1986; 154(5):851-7. Kaplan HS. Disorders of sexual desires and other new concepts and techniques in sex therapy. New York: Brunner/Maazel; 1979. Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology, 33(11):1444-52, 1983. Latif EZ, Diamond MP. Arriving at the diagnosis of female sexual dysfunction. Fertility and Sterilility 2013.Volume 100;4:898-904. Laumann EO, Paik A, Rosen RC. Sexual dysfunction in the United States: prevalence and predictors. JAMA 1999 Feb 10; 281 (6): 537-44. Loureiro P, Oliveira MSP, Girão A. Infecção pelo HTLV. In: Hinrichsen SL (ed.), Doença Infecciosa Parasitária. Editora Guanabara Koogan S. A. cap.9, 65-75p., 2005. Masters WC, Johnson VE. Human sexual response. Boston: Little, Brown; 1966. Mendonça CR, Silva TM, Arrudai JT, Zapata MTAG, Amaral WN. Female sexual function: normal and pathological aspects, prevalence in Brazil, diagnosis and treatment. FEMINA | July / August 2012 | vol 40 | nº 4. Miedany Y, Gaafary M, Aroussy N, et al. Sexual dysfunction in rheumatoid arthritis patients: arthritis and beyond. ClinRheumatol (2012) 31: 601. Moxoto I, Boa-Sorte N, Nunes C, Mota A, Dumas A, Dourado I, Galvão-Castro B. Perfil sociodemográfico, epidemiológico e comportamental de mulheres infectadas pelo HTLV-1 em Salvador-Bahia, uma área endêmica para o HTLV. Revista da Sociedade Brasileira de Medicina Tropical, 40(1):37-1, 2007. Mylonas I. HTLV infectionand its implication in gynecologyandobstetrics. ArchGynecolObstet (2010) 282:493–501. Neal KL, Teng S, Nyamukapa M, Greenberg V, Braverman A, Worly B. Socioeconomic Variables Effecting Female Sexual Function in an Urban, Community Setting. Open Journal of Obstetrics and Gynecology. 2015, 5, 195-202. Nunes, D. et al. HTLV-1 is predominantly sexually transmited in Salvador, the city with the highest HTLV-1 prevalence in Brazil. PloSOne 12(2): e0171303, 2017. Oliveira CJV, Neto JAC, Andrade RCP, et al. Risk Factors for Erectile Dysfunction in Men With HTLV-1. J Sex Med 2017;14:1195-1200. Oliveira JT, Carneiro-Proietti AB, Lima-Martins MV, Martins ML, Proietti FA. Erectile insufficiency as first symptom of HTLV I/II associated myelopathy. Case report. Arq Neuropsiquiatr 1998;56(1):123-125. Oliveira P, Castro NM, Carvalho EM. Urinary and sexual manifestations of patients infected by HTLV-I. Clinics, 62: 191-6, 2007. Oliveira P, Castro NM, Muniz AL, Tanajura D, Brandão JC, Porto AF, Carvalho EM.Prevalence of erectile dysfunction in HTLV-1-infected patients and its association with overactive bladder. Urology, 75: 1100-3, 2010. ________, Oliveira P, Luna T, Souza A, Nascimento M, Siqueira I, Tanajura D, Muniz AL, Glesby MJ, Carvalho EM. Immunological and viral features in patients with overactive bladder associated with human T-cell lymphotropic virus type 1 infection. Journal of Medical Virology, Nov; 84(11):1809-17, 2012. Osame M, Usuku K, Izumo S, Ijichi N, Amitani H, Igata A, Matsumoto M, Tara M. HTLV-1 associated myelopathy, a new clinical entity. Lancet 1986; 1:1031-1032. Osame M. Pathological mechanisms of human T-cell lymphotropic virus type Iassociated myelopathy (HAM/TSP). J Neurovirol. 2002;8(5):359-64. Osame M. Review of WHO Kagoshima meeting and diagnostic guidelines for HAM/TSP. Human retrovirology: HTLV. New York: Raven Press; p 191-197, 1990. Paranhos RF, Paiva MS, Carvalho ES. Sexual and emotional experiences of women with urinary incontinence secondary to HTLV. Acta Paul Enferm. 2016; 29(1):47-52. Poiesz BJ, Ruscetti FW, Gazdar AF, Bunn PA, Minna JD, Gallo RC. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci USA. 1980;77:7415-9. Prado, DS, Mota, VPLP e Lima, TIA Prevalência de disfunção sexual em dois grupos de mulheres de diferentes classes socioeconômicas. RevBrasGinecol Obstet. 2010; 32: 139– 143. Proietti FA, Carneiro-Proietti AB, Catalan-Soares BC, Murphy EL. Global epidemiology of HTLV-I infection and associated diseases. Oncogene. Sep 5; 24(39):6058-68, 2005. Raina R, Pahlajani G, Khan S, Gupta S, Agarwal A, Zippe CD. Female sexual dysfunction: classification, pathophysiology, and management. FertilSteril. 2007;88(5):1273-84. Rathsam-Pinheiro RH, Boa-Sorte N, Castro-Lima-Vargens C, Pinheiro CA, Castro-Lima H, Galvao-Castro B. Ocular lesions in HTLV-1 infected patients from Salvador, State of Bahia: the city with the highest prevalence of this infection in Brazil. Rev Soc Bras Med Trop 2009; 42:633-637. Ribas JGR, Melo GCN. Mielopatia associada ao vírus linfotrópico humano de células T do adulto (HTLV-1). Revista da Sociedade Brasileira de Medicina Tropical.35: 377- 384,2002. Rivemales, Maria da Conceição Costa. Representações sociais sobre a vivência da sexualidade em homens e mulheres soropositivas para o HTLV. Tese (Doutorado) – Universidade Federal da Bahia. Escola de Enfermagem, 2013. Santos FLN, Lima FWM. Epidemiologia, fisiopatogenia e diagnóstico laboratorial da infecção pelo HTLV-I. Jornal Brasileiro de Patologia e Medicina Laboratorial, 41 (2):105-16, 2005. Santos SB, Oliveira P, Luna T, Souza A, Nascimento M, Siqueira I, Tanajura D, Muniz AL, Glesby MJ, Carvalho EM. Immunological and viral features in patients with overactive bladder associated with human T-cell lymphotropic virus type 1 infection. Journal of Medical Virology, Nov;84(11):1809-17, 2012. Santos SB, Porto AF, Muniz AL, de Jesus AR, Magalhães E, Melo A, Dutra WO, Gollob KJ, Carvalho EM. Exacerbated inflammatory cellular immune response characteristics of HAM/TSP is observed in a large proportion of HTLV-1 asymptomatic carriers. BioMed Central Infectious Diseases. 4: 7, 2004. Shrifen JL, Monz BU, Russo PA, Segreti A, Johannes CB. Sexual problems and distress in United States women: prevalence and correlates. ObstetGynecol 2008;112:970–8. Souza A, Tanajura D, Cornell-Toledo C, Santos S, Carvalho EM. Immunopathogenesis and neurological manifestations associated to HTLV-1 infection. Rev. Soc. Bras. Med. Trop. 2012;.45:545-552. Souza-Machado A, Cruz AA, Galvão TS, Carvalho EM. Immunopathogenesis of HTLV-1 infection: influence upon type 2 immune response. Brazilian Journal of Allergy and Immunology, 26(4): 159-67, 2003. Tannus M, Costa DT, Castro NM et al. Immunologic response and proviral load in human T-lymphotropic virus type 1 infected individuals with erectile dysfunction. Urology 2013;81(6):1261-1264. Tzortzis V, Skriapas K, Hadjigeorgiou G, Mitsogiannis I, Aggelakis K, Gravas S, Poulakis V, Melekos MD. Sexual dysfunction in newly diagnosed multiple sclerosis women. MultipleSclerosis14: 561–563, 2008. Uchiyama T, Yodoi J, Sagawa K, Takatsuki K, Uchino H. Adult T-cell leukemia: clinical and hematologic features of 16 cases. Blood, 50: 481-92, 1977. V Tzortzis et al., 2008) Sexual dysfunction in newly diagnosed multiple sclerosis women. MultipleSclerosis 2008; 14: 561–563. Valadares AL, Pinto-Neto AM, Osis MJ, Sousa MH, Costa-Paiva L, Conde DM. Prevalence of sexual dysfunction and its associated factors in women aged 40-65 years with 11 years or more of formal education: a population-based household survey. Clinics. 2008;63(6):775-82. Varjão MS, Alves DB, Andrade –Filho AS, Castro Filho BG. Alterações neurológicas dos pacientes portadores de HTLV-I atendidos no Ambulatório de neurologia do Centro de HTLV na Escola Baiana de Medicina e Saúde Publica (EBMSP). Revista Brasileira de Neurologia e Psiquiatria, 12(1):11-19, 2008. Vaz MI, Coelho MM. A Sexualidade e a Lesão Vertebro-Medular. Acta Urol. 2010;27(2):49-59. Vrielink H, Reesink HW. HTLV-I/II prevalence in different geographic locations. Transfus Med Rev. 2004; 18:46-57. Yamano Y, Araya N, Sato T, Utsunomiya A, Azakami K, Hasegawa D, Izumi T, Fujita H, Aratani S, Yagishita N, Fuji R, Nishioka K, Jacobson S, Nakajima T. Abnormally High leenls of viru- infected IFN-gamma+ CCR4+CD4+ CD25+ Tcells in a retrovirusassociated neuroinflammatory disorder. PLoS One4: 6517, 2009. Yoshilda M. Multiple viral strategies of HTLV-1 for dysregulation of cell growth control. Annual Review of Immunology 19: 475 – 96, 2001.pt_BR
dc.type.degreeMestrado Acadêmicopt_BR
Aparece nas coleções:Dissertação (PPgCS)

Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
Plataforma Sucupira _ DATA DA DEFESA.pdfData de defesa219,5 kBAdobe PDFVisualizar/Abrir
DISSERTAÇÃO Keith Fróes Orrico.pdfDissertação1,37 MBAdobe PDFVisualizar/Abrir
DISSERTAÇÃO Keith Fróes Orrico - Cópia.pdfAnexo241,98 kBAdobe PDFVisualizar/Abrir
Mostrar registro simples do item Visualizar estatísticas


Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.