Aplicabilidade do plasma rico em plaquetas-PRP no tratamento de úlceras em pé de pacientes diabético: revisão sistemática com meta - análise.

Abstract

Introduction: Platelet-rich plasma (PRP) is an innovative, promising technique with significant results in several areas of medicine. The aim of this study is to carry out an evaluation of the results on the applicability of PRP in the treatment of foot ulcers in diabetic patients. Method: This study consists of a systematic review of the specialized literature and meta-analysis of randomized clinical trials in the application of PRP in diabetic foot ulcers. For the elaboration of the research question, the acronym PICOS was used as well as in the orientation in the search strategies. The protocol for this study was registered in the PROSPERO database to register protocols for systematic reviews. The methodology proposed by the Cochrane Collaboration manual was adopted and the PRISMA checklist was used. The AMSTAR 2 tool was used to assess the quality of the review. Inclusion criteria were prospective, randomized clinical studies with no date limit. The forest plot graph was used in the statistical analysis. Results: Of the 154 articles found in the search engine databases, 87 were excluded due to duplication, 58 because they did not meet the inclusion criteria and ended with 09 articles included. Two analyzes were performed, using the outcomes of treatment efficacy and reduction of ulcer size. Seven of the nine articles (408 patients) specified the outcome of treatment effectiveness, with a significant increase in cured patients. The other three articles (224 patients) specified a reduction in the size of the ulcer, being statistically significant in reducing the size of the ulcer. Final considerations: Finally, this SR signaled that the use of platelet derivatives proved to be a good treatment option. Its application was considered a safe, effective and reliable technique to accelerate the healing process of chronic foot ulcers in diabetic patients. It is an organic, autologous, non-toxic and inexpensive preparation. The use of this technique can bring many benefits to these patients and to the public health systems.